INVESTIGATION OF RELATIONSHIP BETWEEN FSHR GENE FUNCTIONALPOLYMORPHISM AT CODON680 AND INFERTILITY IN IRANIAN FEMALES

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SARAFRAZI FERESHTEH; IRANI SHIVA; SAFDARIAN LILI; GHADAMI MOHSEN

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2017 | Volume:7 | Issue:28 Page(s): 79-86

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Title

INVESTIGATION OF RELATIONSHIP BETWEEN FSHR GENE FUNCTIONALPOLYMORPHISM AT CODON680 AND INFERTILITY IN IRANIAN FEMALES

Author(s)

SARAFRAZI FERESHTEH | IRANI SHIVA | SAFDARIAN LILI | GHADAMI MOHSEN | Issue Writer Certificate

Keywords

FOLLICLE STIMULATING HORMONEQ1

FOLLICLE STIMULATING HORMONE RECEPTORQ1

IN-VITROFERTILIZATIONQ2

SINGLE NUCLEOTIDE POLYMORPHISMSQ1

Abstract

Aim and Background: Follicular stimulating hormone (FSH) is a glycoprotein and widely used for the treatment ofinfertility, and its action is mediated by FSH receptor (FSHR). There are several SNPs inFSHR gene of which determine the ovarian response to FSH. One of them is located atposition 680 (Asparagine (N) to Serine (S)). Polymorphic sites give rise to three discretevariants of FSHR: NN, NS, and SS. We evaluated this functional polymorphism site inIranian infertile women who undergo in vitro fertilization (either successful or failed). Materials and Methods: 31 incident cases and 30 controls were analyzed using PCR and direct sequencing forAsn/Ser at position 680 polymorphism. Results: In normal group Ser680/Ser680 genotype was more frequent than infertile patients. These findings failed to support the relationship between this polymorphism and infertility inevaluated Iranian women. However the total amount of FSH consumed by Ser680 in infertilepatients was more than that was used by Asn680 group. A logistic regression analysisbetween the groups with Ser680 and Asn680 showed that Ser680 showed poor response toFSH. Conclusions: Our results suggested that Asn680Ser polymorphism can be used as a markerfor considering FSH dosage in patients undergoing IVF, and a personalized FSH therapy maybe applied based on patientś genotype at this polymorphism site in clinical setting.

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APA: Copy

SARAFRAZI, FERESHTEH, IRANI, SHIVA, SAFDARIAN, LILI, & GHADAMI, MOHSEN. (2017). INVESTIGATION OF RELATIONSHIP BETWEEN FSHR GENE FUNCTIONALPOLYMORPHISM AT CODON680 AND INFERTILITY IN IRANIAN FEMALES. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 7(28 ), 79-86. SID. https://sid.ir/paper/204487/en

Vancouver: Copy

SARAFRAZI FERESHTEH, IRANI SHIVA, SAFDARIAN LILI, GHADAMI MOHSEN. INVESTIGATION OF RELATIONSHIP BETWEEN FSHR GENE FUNCTIONALPOLYMORPHISM AT CODON680 AND INFERTILITY IN IRANIAN FEMALES. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2017;7(28 ):79-86. Available from: https://sid.ir/paper/204487/en

IEEE: Copy

FERESHTEH SARAFRAZI, SHIVA IRANI, LILI SAFDARIAN, and MOHSEN GHADAMI, “INVESTIGATION OF RELATIONSHIP BETWEEN FSHR GENE FUNCTIONALPOLYMORPHISM AT CODON680 AND INFERTILITY IN IRANIAN FEMALES,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 7, no. 28 , pp. 79–86, 2017, [Online]. Available: https://sid.ir/paper/204487/en

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