Induction of programmed cell death by “ Retinoic acid, Formylindolo (3, 2-b) carbazole”-enhanced monoclonal antibody against CD44 in acute promyelocytic leukemia cells patients.

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AMANZADEH AMIR; MOLLA KAZEMIHA VAHID; HABIBI ANBOUHI MAHDI; AZADMANESH KAYHAN; MOUSAVI SEYED ASADOLLAH; ABOLHASSANI MOHSEN; SHOKRGOZAR MOHAMMAD ALI

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Journal: NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL Year:2018 | Volume:8 | Issue:31 Page(s): 9-17

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Title

Induction of programmed cell death by “ Retinoic acid, Formylindolo (3, 2-b) carbazole”-enhanced monoclonal antibody against CD44 in acute promyelocytic leukemia cells patients.

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Keywords

Acute Promyelocytic LeukemiaQ1

Anti CD44 Monoclonal AntibodyQ1

Retinoic AcidQ1

Synergy.Q1

Abstract

Aim and Background: The aim of this study was to enhance the synergistic effect of the "RA-FICZ" by adding Anti CD44 Monoclonal Antibody (mAb), to induce myeloid differentiation and apoptosis in three patients with APL. Materials and methods: The anti-CD44 antibody concentrations of 5 to 25 μ g/ml prepared and added to "RA-FICZ" complex and Isolated Cells from Patients. The antibody optimum concentration was determined then neutrophil maturation, apoptosis and expression of CD14 and CD11b were analyzed by flow cytometry. Results: Adding the different concentrations of CD44 mAb against CD44 improved the ability of promyelocytes differentiation and led to increased expression of CD11b and CD14 antigens more than two times. The apoptotic rate increased up to 66%. Conclusion: Additional studies and work on the animal models can lead to a reduction even elimination of the chemotherapy. This triple combination" can be candidate as a novel differentiation-inducing therapy in APL cells.

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APA: Copy

AMANZADEH, AMIR, MOLLA KAZEMIHA, VAHID, HABIBI ANBOUHI, MAHDI, AZADMANESH, KAYHAN, MOUSAVI, SEYED ASADOLLAH, ABOLHASSANI, MOHSEN, & SHOKRGOZAR, MOHAMMAD ALI. (2018). Induction of programmed cell death by “ Retinoic acid, Formylindolo (3, 2-b) carbazole”-enhanced monoclonal antibody against CD44 in acute promyelocytic leukemia cells patients.. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, 8(31 ), 9-17. SID. https://sid.ir/paper/204708/en

Vancouver: Copy

AMANZADEH AMIR, MOLLA KAZEMIHA VAHID, HABIBI ANBOUHI MAHDI, AZADMANESH KAYHAN, MOUSAVI SEYED ASADOLLAH, ABOLHASSANI MOHSEN, SHOKRGOZAR MOHAMMAD ALI. Induction of programmed cell death by “ Retinoic acid, Formylindolo (3, 2-b) carbazole”-enhanced monoclonal antibody against CD44 in acute promyelocytic leukemia cells patients.. NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL[Internet]. 2018;8(31 ):9-17. Available from: https://sid.ir/paper/204708/en

IEEE: Copy

AMIR AMANZADEH, VAHID MOLLA KAZEMIHA, MAHDI HABIBI ANBOUHI, KAYHAN AZADMANESH, SEYED ASADOLLAH MOUSAVI, MOHSEN ABOLHASSANI, and MOHAMMAD ALI SHOKRGOZAR, “Induction of programmed cell death by “ Retinoic acid, Formylindolo (3, 2-b) carbazole”-enhanced monoclonal antibody against CD44 in acute promyelocytic leukemia cells patients.,” NEW CELLULAR & MOLECULAR BIOTECHNOLOGY JOURNAL, vol. 8, no. 31 , pp. 9–17, 2018, [Online]. Available: https://sid.ir/paper/204708/en

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