STUDY OF CYTOPLASMIC GAMMA- TUBULIN DISTRIBUTION IN DIFFERENTIATED HUMAN LEUKEMIA CELLS BY TEM

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AHMADIAN SH.

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Paper Information

Journal: JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT) Year:2007 | Volume:32 | Issue:4 (SECTION: BIOLOGY 2) Page(s): 341-345

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Title

STUDY OF CYTOPLASMIC GAMMA- TUBULIN DISTRIBUTION IN DIFFERENTIATED HUMAN LEUKEMIA CELLS BY TEM

Author(s)

AHMADIAN SH. | Issue Writer Certificate

Keywords

GAMMA- TUBULINQ3

MICROTUBULEQ3

IMMUNO-GOLD ELECTRON MICROSCOPYQ3

HL-60 CELLSQ3

Abstract

Control of MICROTUBULE nucleation is important for many MICROTUBULE dependent processes in cells.Gamma-tubulin is a universal component of MICROTUBULE organizing centers where it is believed to play an important role in the nucleation of MICROTUBULE polymerization. Gamma-tubulin also exists as part of a cytoplasmic complex whose size and com-plexity varies in different organisms. To investigate the distribution of gamma-tubulin in differentiated leukemia cells, HL-60 cell lines were induced to differentiate by All-trans retinoic acid (ATRA). We used pre-embedding IMMUNO-GOLD ELECTRON MICROSCOPY and a monoclonal antibody against gamma-tubulin in undifferentiated and induced different-iated HL-60 CELLS. The results revealed that in un-differentiated cells, gamma-tubulin is mostly found in the pericenriolarregion, but in differentiated cells, besides the centriolar region, the amount of gamma-tubulin showed a significant increase in non-centrosomal regional of cytoplasm.These results suggest that the non-centrosomal gamma-tubulin complex plays a role in nucleation of MICROTUBULE in ATRA induced differentiated HL- 60 cells. Further, the cytoplasmic gamma-tubulin complex in different-iated cells is more abundant than undifferentiated cells.

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APA: Copy

AHMADIAN, SH.. (2007). STUDY OF CYTOPLASMIC GAMMA- TUBULIN DISTRIBUTION IN DIFFERENTIATED HUMAN LEUKEMIA CELLS BY TEM. JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT), 32(4 (SECTION: BIOLOGY 2)), 341-345. SID. https://sid.ir/paper/2064/en

Vancouver: Copy

AHMADIAN SH.. STUDY OF CYTOPLASMIC GAMMA- TUBULIN DISTRIBUTION IN DIFFERENTIATED HUMAN LEUKEMIA CELLS BY TEM. JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT)[Internet]. 2007;32(4 (SECTION: BIOLOGY 2)):341-345. Available from: https://sid.ir/paper/2064/en

IEEE: Copy

SH. AHMADIAN, “STUDY OF CYTOPLASMIC GAMMA- TUBULIN DISTRIBUTION IN DIFFERENTIATED HUMAN LEUKEMIA CELLS BY TEM,” JOURNAL OF SCIENCE (UNIVERSITY OF TEHRAN) (JSUT), vol. 32, no. 4 (SECTION: BIOLOGY 2), pp. 341–345, 2007, [Online]. Available: https://sid.ir/paper/2064/en

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