HYPOGLYCEMIC ANY HYPOLIPIDIC EFFECTS OF CYNARA SCOLYMUS “FAMILY OF COMPOSITAE” ONALLOXAN DIABETIC RATS COMPARED WITH GALIBENGLAMID

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MADANI HOSSEIN; TALEB ALHOSSEINI M.; AHMADI MAHMOUDABADI NARGOL; MAHZOUNI P.; VAHDATI AKBAR; MASAELI SH.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2009 | Volume:22 | Issue:2 Page(s): 371-380

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Title

HYPOGLYCEMIC ANY HYPOLIPIDIC EFFECTS OF CYNARA SCOLYMUS “FAMILY OF COMPOSITAE” ONALLOXAN DIABETIC RATS COMPARED WITH GALIBENGLAMID

Author(s)

Keywords

DIABETICQ2

CYNARA SCOLYMUS L.Q3

ALLOXAN MONOHYDRATEQ3

GALIBENGLAMIDQ3

Abstract

Cynara scolymus L. is a plant from the Compositae family which is used in herbal medicine. In this study, the effects of hydroalchoholic extract of Cynara scolymus, on the amount of glucose, lipids and lipoprotein in ALLOXAN MONOHYDRATE diabeties rats were investigated, and compared with GALIBENGLAMID as antiDIABETIC drug. The pancreatic tissues were investigated. In order to perform this study, 20 adult male rats were used, and divided in 4 groups of each five rats. Group 1 served normal control and in each injection received only normal saline. The second group is treated with ALLOXAN MONOHYDRATE at a dosis of 20mg/kg.bw. In the 3rd and 4th groups, in addition to alloxan, GALIBENGLAMID (0.5 mg/kg) and hydroalchoholic extract of Cynara scolymus (300mg/kg) were administered respectively. 48 hours after the last injection, blood sampling was performed by cardiac puncture to measure serum factors. The results have proves that the extract of cynara, the level of glucose, cholesterol, triglycerids, VLDL, and LDL, iv comparation with the DIABETIC groups, is significantly reduced but the level of HDL is increased(p<0.05). The effect of cynara on all studied factors is evident and is equal to the group of GALIBENGLAMID (p>0.05). The pathological results on damaged tissue shows that the pancreatic islets have grown significantly, the amount of cell proliferation the islets and the rate of cell growth is estimulated in compared with DIABETIC group. This research has shown that the hydroalchoholic extract of cynara has a reducing effect on glucose, lipids and lipoprotein in the serum of DIABETIC rats. This extract is very effective in the revitalization of damaged pancreatic tissues. Therefore extract of Cynara scolymus has antiDIABETIC effects.

Cites

EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS

References

PHARMACOGNOSICAL & PLANT TISSUE CULTURE STUDIES OF MELISSA OFFICINALIS L

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APA: Copy

MADANI, HOSSEIN, TALEB ALHOSSEINI, M., AHMADI MAHMOUDABADI, NARGOL, MAHZOUNI, P., VAHDATI, AKBAR, & MASAELI, SH.. (2009). HYPOGLYCEMIC ANY HYPOLIPIDIC EFFECTS OF CYNARA SCOLYMUS “FAMILY OF COMPOSITAE” ONALLOXAN DIABETIC RATS COMPARED WITH GALIBENGLAMID. IRANIAN JOURNAL OF BIOLOGY, 22(2), 371-380. SID. https://sid.ir/paper/21070/en

Vancouver: Copy

MADANI HOSSEIN, TALEB ALHOSSEINI M., AHMADI MAHMOUDABADI NARGOL, MAHZOUNI P., VAHDATI AKBAR, MASAELI SH.. HYPOGLYCEMIC ANY HYPOLIPIDIC EFFECTS OF CYNARA SCOLYMUS “FAMILY OF COMPOSITAE” ONALLOXAN DIABETIC RATS COMPARED WITH GALIBENGLAMID. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2009;22(2):371-380. Available from: https://sid.ir/paper/21070/en

IEEE: Copy

HOSSEIN MADANI, M. TALEB ALHOSSEINI, NARGOL AHMADI MAHMOUDABADI, P. MAHZOUNI, AKBAR VAHDATI, and SH. MASAELI, “HYPOGLYCEMIC ANY HYPOLIPIDIC EFFECTS OF CYNARA SCOLYMUS “FAMILY OF COMPOSITAE” ONALLOXAN DIABETIC RATS COMPARED WITH GALIBENGLAMID,” IRANIAN JOURNAL OF BIOLOGY, vol. 22, no. 2, pp. 371–380, 2009, [Online]. Available: https://sid.ir/paper/21070/en

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