EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS

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POURABOLI I.; RANJBAR B.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2011 | Volume:24 | Issue:5 Page(s): 679-687

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Information Journal Paper

Title

EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS

Author(s)

POURABOLI I. | RANJBAR B. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

DAUCUS CAROTA SEEDSQ2

GLUCOSEQ2

LIPIDSQ2

LIPOPROTEINSQ2

Abstract

Daucus carota seeds have different antioxidant agents and with respect to role of antioxidants in improvement of DIABETES MELLITUS in this study the effect of alcoholic extract of D. carota seeds on serum levels of GLUCOSE, LIPIDS and LIPOPROTEINS was investigated in type I diabetic male rats. Type I DIABETES MELLITUS was induced in male wistar rats by injection of 70 mg/kg, i.p of streptozotocin. Before this and 5 days post injection blood samples were collected for measurement serum levels of GLUCOSE, triglycerides, cholesterol and LIPOPROTEINS. Diabetes was confirmed in rats having FBS above 250 mg/dL. Diabetic animals were divided to 5 groups received 100, 200, 300 mg/kg of extract, 600 mg/kg glibenclamide and 0.5 mL distilled water individually by gavage for 3 days. After 3 days rats sacrificed by decapitation and fasting blood samples were collected from cervical vein and above factors were measured with commercial kits by spectrophotometery. Results showed that administration of D. carota seeds extract (300 mg/kg) for 3 days decreased GLUCOSE serum level (p<0.05). Also extract at all doses decreased triglycerides, at dose 200 and 300 mg/kg decreased cholesterol and only at dose 200 mg/kg decreased LDL and VLDL serum levels (p<0.05). Thus it seems administration of D. carota seeds extract for 3 days has hypoglycemic and especially antihyperlipidemic effects in type I diabetic rats.

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APA: Copy

POURABOLI, I., & RANJBAR, B.. (2011). EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS. IRANIAN JOURNAL OF BIOLOGY, 24(5), 679-687. SID. https://sid.ir/paper/21299/en

Vancouver: Copy

POURABOLI I., RANJBAR B.. EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2011;24(5):679-687. Available from: https://sid.ir/paper/21299/en

IEEE: Copy

I. POURABOLI, and B. RANJBAR, “EFFECT OF DAUCUS CAROTA SEEDS EXTRACT ON SERUM LEVELS OF GLUCOSE, LIPIDS AND LIPOPROTEINS IN TYPE I DIABETIC MALE RATS,” IRANIAN JOURNAL OF BIOLOGY, vol. 24, no. 5, pp. 679–687, 2011, [Online]. Available: https://sid.ir/paper/21299/en

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