THE ROLE OF GABA-B RECEPTORS OF NBM IN LEARNING AND MEMORY

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NOURJAH P.; ROSTAMI P.; BARZEGAR BEFROUEI M.H.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2007 | Volume:20 | Issue:3 Page(s): 278-287

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Information Journal Paper

Title

THE ROLE OF GABA-B RECEPTORS OF NBM IN LEARNING AND MEMORY

Author(s)

NOURJAH P. | ROSTAMI P. | BARZEGAR BEFROUEI M.H. | Issue Writer Certificate

Keywords

GABA-BQ3

NBM (NUCLEUS BASALIS OF MEYNERT)Q3

LEARNINGQ2

MEMORYQ3

RATQ2

Abstract

The discovery of different GABA receptor subtypes has stimulated research relating this neurotransmitter to a variety of behavioral and clinical disorders. The development of new and specific GABA ergic compounds has made it possible to try to identify the specific function of these receptors. The purpose of the present study is to evaluate the role of GABA-B receptor subtype of Nucleus Basalis of Meynert (NBM) in LEARNING and MEMORY. The RATs implanted with unilateral intra- NBM guide cannulae and trained on a step- through inhibitory avoidance apparatus. One day later, retention was tested. The doses .0.01, 0.05 and 0.1 mg of Baclofen a GABA-B receptors, agonist in 0.5ml salin were injected through cannulae in NBM. Results show that doses of 0.05 and 0.1 mg of Baclofen impaired retention, while dose of 0.01 mg of this drug has no effect. The doses 0.1, 0.5 and 1 mg of CGP35348 in 0.5 ml salin were injected in NBM. CGP35348 is an antagonist of GABA-B receptors. Results show that doses of 0.5 and 1 mg CGP35348 enhanced retention of inhibitory passive avoidance conditioning. Then the combination of Baclofen and CGP were injected. The results show that 0.05 mg Baclofen + 0.5 mg CGP has no effect on the retention , while 1 mg CGP + 0.05 mg Baclofen improved retention and 1 mg CGP + 0.1 mg Baclofen , 0.1 mg Baclofen , 0.1 mg CGP + 0.1 mg Baclofen and 0.5 mg CGP + 0.1 mg Baclofen impaired retention. It is concluded that GABA-B receptors stimulation within NBM causes retention impairment and also GABA-B receptors inhibition induce retention enhancement. In addition injection of CGP35348 intra-NBM improves retention impairment induced by Baclofen administration.

Cites

THE EFFECTS OF INTRAHIPPOCAMPUS INJECTION OF PROGESTERONE ON PASSIVE AVOIDANCE LEARNING AND MEMORY IN ADULT MALE RATS

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APA: Copy

NOURJAH, P., ROSTAMI, P., & BARZEGAR BEFROUEI, M.H.. (2007). THE ROLE OF GABA-_B RECEPTORS OF NBM IN LEARNING AND MEMORY. IRANIAN JOURNAL OF BIOLOGY, 20(3), 278-287. SID. https://sid.ir/paper/21104/en

Vancouver: Copy

NOURJAH P., ROSTAMI P., BARZEGAR BEFROUEI M.H.. THE ROLE OF GABA-_B RECEPTORS OF NBM IN LEARNING AND MEMORY. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2007;20(3):278-287. Available from: https://sid.ir/paper/21104/en

IEEE: Copy

P. NOURJAH, P. ROSTAMI, and M.H. BARZEGAR BEFROUEI, “THE ROLE OF GABA-_B RECEPTORS OF NBM IN LEARNING AND MEMORY,” IRANIAN JOURNAL OF BIOLOGY, vol. 20, no. 3, pp. 278–287, 2007, [Online]. Available: https://sid.ir/paper/21104/en

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