THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES

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MIRRAZAVI M.; SABOUNI F.; ABBASI SH.; HAGHBIN K.; HAJIHOSSEINI R.; NAZEM H.A.

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Journal: IRANIAN JOURNAL OF BIOLOGY Year:2012 | Volume:25 | Issue:3 Page(s): 358-365

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Title

THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES

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Keywords

ASTROCYTEQ2

TOXICITYQ2

SHIKONINQ2

Abstract

ASTROCYTEs are the aboundent cell type in the central nervous system. They play role in maintenance of normal brain physiology. In addition, ASTROCYTEs become reactive during injury of the central nervous system and have important roles during CNS inflammation. SHIKONIN, is a main compound of the roots of Lithospermum erythrohizon and Arnebia euchroma that has various biological activities, including antiinflammatory, anti- HIV1, antimicrobial, anti- thrombotic and anti-tumor properties.The aim of the present study was to investigate the cytotoxic effects of different concentration (20mM-5mM) of SHIKONIN on primary ASTROCYTEs and cell line 1321N1. We used MTT reaction to assay cell viability and stained the cells with DAPI to investigate the cell death. The results show that SHIKONIN have dose dependent effects on this cells, in high concentration it is toxic for cells but in its low concentration SHIKONIN has not the cytotoxic effect on cells.

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APA: Copy

MIRRAZAVI, M., SABOUNI, F., ABBASI, SH., HAGHBIN, K., HAJIHOSSEINI, R., & NAZEM, H.A.. (2012). THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES. IRANIAN JOURNAL OF BIOLOGY, 25(3), 358-365. SID. https://sid.ir/paper/21450/en

Vancouver: Copy

MIRRAZAVI M., SABOUNI F., ABBASI SH., HAGHBIN K., HAJIHOSSEINI R., NAZEM H.A.. THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES. IRANIAN JOURNAL OF BIOLOGY[Internet]. 2012;25(3):358-365. Available from: https://sid.ir/paper/21450/en

IEEE: Copy

M. MIRRAZAVI, F. SABOUNI, SH. ABBASI, K. HAGHBIN, R. HAJIHOSSEINI, and H.A. NAZEM, “THE INVESTIGATION OF CYTOTOXIC EFFECTS OF STANDARD SHIKONIN AND EXTRACTION SHIKONIN FROM ARNEBIA EUCHROMA ON ASTROCYTES,” IRANIAN JOURNAL OF BIOLOGY, vol. 25, no. 3, pp. 358–365, 2012, [Online]. Available: https://sid.ir/paper/21450/en

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