HEPATOPROTECTIVE EFFECTS OF SILYBUM MARIANUM AND CALENDULA OFFICINALIS POLYPHENOLIC EXTRACTS IN RAT

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MADANI SEYED HOSSEIN; TALEB ALHOSSEINI M.; ASGARY SEDIGHEH; NADERI GH.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF BIOLOGY Year:2006 | Volume:19 | Issue:2 Page(s): 157-163

Download Full-Text

Persian Verion

View:

1,144

Download:

Cites:

Information Journal Paper

Title

HEPATOPROTECTIVE EFFECTS OF SILYBUM MARIANUM AND CALENDULA OFFICINALIS POLYPHENOLIC EXTRACTS IN RAT

Author(s)

MADANI SEYED HOSSEIN | TALEB ALHOSSEINI M. | ASGARY SEDIGHEH | NADERI GH.A. | Issue Writer Certificate

Keywords

HEPATOPROTECTIVEQ3

THIOACETAMIDEQ2

SILYBUM MARIANUMQ3

CALENDULA OFFICINALISQ2

Abstract

Plants consumed humans contain thousands of phenolic compoounds. The effects of dietary polyphenols are of great current interest due to their antioxidative and possible anticarcinogenic activities. Liver is one of the organ in body that exposure with many of oxidant and carcinogen agents thus antioxidant compounds are beneficial for liver healt. In this study was an investigation protective effect of SILYBUM MARIANUM and caliendula officinalis against THIOACETAMIDE-induced hepatotoxicity in rat. After extraction and purification, the extracts were injected at a dosis of 25mg/Kg together with THIOACETAMIDE at a dosis of 50mg/Kg (P.C.). After blood collection and separation of serum, activities of aminotrasferases (SGOT and SGPT), alkalin phosphatas, Bilirubin, Na+ and K+ were measured in serum. Significant decrease in activity of aminotrasferases, alkalin phosphatas and Bilirubin were observed in groups treated with extracts in compared with THIOACETAMIDE treated group. These result show that protective effects of these extracts against the THIOACETAMIDE induced hepatotoxicity that may be due to its ability to block the bioactivation of THIOACETAMIDE, primarily by inhibitig the activity of Cyt P450 and its free radical scavenging.

Cites

No record.

References

No record.

Cite

Related Journal Papers