HEPATOPROTECTIVE EFFECT OF CHICHORIUM INTYBUS L. ON LIVER TOXICITY IN RAT

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MADANI H.; ASGARI SEDIGHEH; NADERI GH.; TALEBOLHOSEINI M.

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Journal: Journal of Medicinal Plants Year:2006 | Volume:5 | Issue:17 Page(s): 32-38

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Title

HEPATOPROTECTIVE EFFECT OF CHICHORIUM INTYBUS L. ON LIVER TOXICITY IN RAT

Author(s)

MADANI H. | ASGARI SEDIGHEH | NADERI GH. | TALEBOLHOSEINI M. | Issue Writer Certificate

Keywords

ANTIOXIDANTSQ2

HEPATOPROTECTIVEQ4

POLYPHENOLIC COMPOUNDSQ3

THIOACETAMIDEQ4

SILYBUM MARIANUMQ3

CHICHORIUM INTYBUSQ2

Abstract

Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent HEPATOPROTECTIVE effects. Objective: In this study, we have investigated the protective effects of polyphenolic extracts of SILYBUM MARIANUM and CHICHORIUM INTYBUS on thioacethamide-induced hepatotoxicity in rat. Methods: Extracts were injected to rats, at a dose of 25 mg/kg body weight together with THIOACETAMIDE at a dose of 50 mg/kg body weight. For investigation of the HEPATOPROTECTIVE effect of extracts against THIOACETAMIDE, activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilyrubin, Na+ and K+ were measured. Results: significant decreases were observed in activities of aminotransferases, alkalin phosphatase and bilyrubin in groups that treated with extracts together with THIOACETAMIDE in comparation with THIOACETAMIDE treated group. Level of Na+,K+ and liver weight betwen different groups had not significant different. Conclusions: This results showed protective effect of chichorium extracts on THIOACETAMIDE-induced hepatotoxicity in rat.

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APA: Copy

MADANI, H., ASGARI, SEDIGHEH, NADERI, GH., & TALEBOLHOSEINI, M.. (2006). HEPATOPROTECTIVE EFFECT OF CHICHORIUM INTYBUS L. ON LIVER TOXICITY IN RAT. JOURNAL OF MEDICINAL PLANTS, 5(17), 32-38. SID. https://sid.ir/paper/15542/en

Vancouver: Copy

MADANI H., ASGARI SEDIGHEH, NADERI GH., TALEBOLHOSEINI M.. HEPATOPROTECTIVE EFFECT OF CHICHORIUM INTYBUS L. ON LIVER TOXICITY IN RAT. JOURNAL OF MEDICINAL PLANTS[Internet]. 2006;5(17):32-38. Available from: https://sid.ir/paper/15542/en

IEEE: Copy

H. MADANI, SEDIGHEH ASGARI, GH. NADERI, and M. TALEBOLHOSEINI, “HEPATOPROTECTIVE EFFECT OF CHICHORIUM INTYBUS L. ON LIVER TOXICITY IN RAT,” JOURNAL OF MEDICINAL PLANTS, vol. 5, no. 17, pp. 32–38, 2006, [Online]. Available: https://sid.ir/paper/15542/en

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