EFFICACY OF THE PROPHYLACTIC DOSE OF TRANEXAMIC ACID IN THE AMOUNT OF BLEEDING DURING MANDIBULAR SURGERIE: A RANDOMIZED DOUBLE-BLINDED CLINICAL TRIAL

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HADDADI SOUDABEH; PARVIZI ARMAN; FADAEE NAINEE ALIREZA; ATRKAR ROSHAN ZAHRA; NADERI NABI BAHRAM; ARGHAND SAKINEH

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Journal: Journal of Anesthesiology and Pain Year:2015 | Volume:5 | Issue:3 Page(s): 16-24

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Title

EFFICACY OF THE PROPHYLACTIC DOSE OF TRANEXAMIC ACID IN THE AMOUNT OF BLEEDING DURING MANDIBULAR SURGERIE: A RANDOMIZED DOUBLE-BLINDED CLINICAL TRIAL

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Keywords

TRANEXAMIC ACIDQ2

BLEEDINGQ2

MANDIBULAR SURGERYQ2

HEMOGLOBINQ3

HEMATOCRITQ3

Abstract

Aim and Background: TRANEXAMIC ACID has been used to reduce blood loss and the need for blood transfusion in many surgeries. Traumatic mandibular surgeries can be associated with significant BLEEDING which affects the field of operation and creates difficulties for the surgeon. Therefore we decided to evaluate the effect of TRANEXAMIC ACID on the amount of BLEEDING during traumatic mandibular surgeries.Methods and Materials: In this randomized double blinded clinical trail, 90 patients, scheduled for traumatic mandibular surgeries with ASA class I-II and aged between 18 to 40 years, were included. They were randomly assigned to each group (n=45). After induction of general anesthesia with the same plan; they received TRANEXAMIC ACID (10 mg/kg) or equal volume of normal saline, intravenously. Intra operative BLEEDING, pre-op HEMOGLOBIN (Hb), HEMATOCRIT (Hct) concentration, post-op (after 6 hours) Hb and Hct concentration, rate of blood transfusion and the quality of surgical field were recorded for each patient. Then data analyisis was performed with (SPSS software version 16).Findings: Mean intraoperative BLEEDING in the TRANEXAMIC ACID and placebo group were 80.44±49.43 ml and 183.0±69.53ml, respectively (P=0.0001). Post-op decreasing rate of Hb and Hct were less in the TRANEXAMIC ACID group vs. the control one (P=0.0001 for Hb, P=0.001 for Hct). The Quality of surgical field leading to the surgeon’s satisfaction was better in the tranexamic group than the control group. (P=0.0001). None of the patients needed blood transfusion. Adverse effects were not seen in any of the groups.Conclusions: Administration of IV TRANEXAMIC ACID decreases the amount of BLEEDING during mandibular surgeries.

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APA: Copy

HADDADI, SOUDABEH, PARVIZI, ARMAN, FADAEE NAINEE, ALIREZA, ATRKAR ROSHAN, ZAHRA, NADERI NABI, BAHRAM, & ARGHAND, SAKINEH. (2015). EFFICACY OF THE PROPHYLACTIC DOSE OF TRANEXAMIC ACID IN THE AMOUNT OF BLEEDING DURING MANDIBULAR SURGERIE: A RANDOMIZED DOUBLE-BLINDED CLINICAL TRIAL. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), 5(3), 16-24. SID. https://sid.ir/paper/216224/en

Vancouver: Copy

HADDADI SOUDABEH, PARVIZI ARMAN, FADAEE NAINEE ALIREZA, ATRKAR ROSHAN ZAHRA, NADERI NABI BAHRAM, ARGHAND SAKINEH. EFFICACY OF THE PROPHYLACTIC DOSE OF TRANEXAMIC ACID IN THE AMOUNT OF BLEEDING DURING MANDIBULAR SURGERIE: A RANDOMIZED DOUBLE-BLINDED CLINICAL TRIAL. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)[Internet]. 2015;5(3):16-24. Available from: https://sid.ir/paper/216224/en

IEEE: Copy

SOUDABEH HADDADI, ARMAN PARVIZI, ALIREZA FADAEE NAINEE, ZAHRA ATRKAR ROSHAN, BAHRAM NADERI NABI, and SAKINEH ARGHAND, “EFFICACY OF THE PROPHYLACTIC DOSE OF TRANEXAMIC ACID IN THE AMOUNT OF BLEEDING DURING MANDIBULAR SURGERIE: A RANDOMIZED DOUBLE-BLINDED CLINICAL TRIAL,” JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), vol. 5, no. 3, pp. 16–24, 2015, [Online]. Available: https://sid.ir/paper/216224/en

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