THE EFFECTIVENESS COMPARISON OF PALONOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING GENERAL ANESTHESIA: A META-ANALYSIS AND SYSTEMATIC REVIEW

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SABZALIZADEH SAMANEH; RAVAGHI HAMID; SALEHI MASOUD; DELSHAD VAHID

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Journal: Journal of Anesthesiology and Pain Year:2016 | Volume:6 | Issue:2 Page(s): 66-76

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Title

THE EFFECTIVENESS COMPARISON OF PALONOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING GENERAL ANESTHESIA: A META-ANALYSIS AND SYSTEMATIC REVIEW

Author(s)

SABZALIZADEH SAMANEH | RAVAGHI HAMID | SALEHI MASOUD | DELSHAD VAHID | Issue Writer Certificate

Keywords

ONDANSETRONQ2

PALONOSETRONQ2

POSTOPERATIVE NAUSEA AND VOMITINGQ3

GENERAL ANESTHESIAQ3

Abstract

Aims and Background: Nausea and vomiting after surgery is one of the undesirable complications which occurs in more than %30 of patients. In the meanwhile, Serotonin antagonists have an expanded function in prevention of POSTOPERATIVE NAUSEA AND VOMITING. The aim of this research was to compare the effectiveness of ONDANSETRON and PALONOSETRON(Serotonin antagonist) in this regard.Methods and materials: This research has been an organized review with Meta-analysis. Search process has been done in Data bases namely: Clinicaltrials.Gov, CRD Database, Cochrane Systematic Review, Clinical key, and Pub Med; just RCT articles, which compared incidence of POSTOPERATIVE NAUSEA AND VOMITING under GENERAL ANESTHESIA, have been chosen. After search and evaluation, 8 articles entered Meta-analysis. Risk estimation integration, and risk ratio calculation were analyzed via STATA 13.Findings: Number of samples in articles were 739. The incidence of POSTOPERATIVE NAUSEA AND VOMITING was assessed until 24 hours after surgery in 389 persons. Data analysis during 0 to 24 hours showed that PALONOSETRON decreased the incidence of nausea by %50, and the incidence of vomiting by 79% in comparison with ONDANSETRON (p=0.001).Conclusions: Evaluating the effect of 0.075 mg PALONOSETRON versus 4mg of ONDANSETRON in primary 24 hours past surgery demonstrated that Palonestron has more efficiency on incidence reduction of Nausea and Vomiting, compared to ONDANSETRON in patients.

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APA: Copy

SABZALIZADEH, SAMANEH, RAVAGHI, HAMID, SALEHI, MASOUD, & DELSHAD, VAHID. (2016). THE EFFECTIVENESS COMPARISON OF PALONOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING GENERAL ANESTHESIA: A META-ANALYSIS AND SYSTEMATIC REVIEW. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), 6(2), 66-76. SID. https://sid.ir/paper/216254/en

Vancouver: Copy

SABZALIZADEH SAMANEH, RAVAGHI HAMID, SALEHI MASOUD, DELSHAD VAHID. THE EFFECTIVENESS COMPARISON OF PALONOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING GENERAL ANESTHESIA: A META-ANALYSIS AND SYSTEMATIC REVIEW. JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN)[Internet]. 2016;6(2):66-76. Available from: https://sid.ir/paper/216254/en

IEEE: Copy

SAMANEH SABZALIZADEH, HAMID RAVAGHI, MASOUD SALEHI, and VAHID DELSHAD, “THE EFFECTIVENESS COMPARISON OF PALONOSETRON WITH ONDANSETRON IN PREVENTING POSTOPERATIVE NAUSEA AND VOMITING IN PATIENT UNDERGOING GENERAL ANESTHESIA: A META-ANALYSIS AND SYSTEMATIC REVIEW,” JOURNAL OF ANESTHESIOLOGY AND PAIN (PERSIAN), vol. 6, no. 2, pp. 66–76, 2016, [Online]. Available: https://sid.ir/paper/216254/en

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