MICROSCOPIC ASSESSMENT OF THE EFFECTS OF CHEMORADIOTHERAPY ON NORMAL ORAL MUCOSA IN PATIENTS WITH HEAD AND NECK CANCER

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MASHHADI ABBAS F.; MIRZAEI HAMID REZA; AKBARZADEH BAGHBAN A.R.; RAZAVI A.A.

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Journal: Journal of Dental School Year:2008 | Volume:26 | Issue:3 (77) Page(s): 326-333

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Title

MICROSCOPIC ASSESSMENT OF THE EFFECTS OF CHEMORADIOTHERAPY ON NORMAL ORAL MUCOSA IN PATIENTS WITH HEAD AND NECK CANCER

Author(s)

MASHHADI ABBAS F. | MIRZAEI HAMID REZA | AKBARZADEH BAGHBAN A.R. | RAZAVI A.A. | Issue Writer Certificate

Keywords

HEAD AND NECK CANCERQ2

ORAL MUCOSAQ2

CYTOLOGYQ3

CHEMORADIOTHERAPQ3

Abstract

Background and Aim: There are only few studies about effect of CHEMORADIOTHERAPybased on cellular level. The aim of this study was to evaluate the effects of such treatment on normal cells of ORAL MUCOSA.Materials & Methods: Seventy patients whose normal ORAL MUCOSA was exposed to radiation during the course of CHEMORADIOTHERAPywere selected. Before starting the treatment, 2 slides from the normal ORAL MUCOSA were prepared for each patient, one from keratinized and one from non-keratinized mucosa. At the end of treatment 2 other slides were taken from the same area too. After observing the slides under light microscope in blind form, the results of the observation from the first slides were compared with the results of the second one. Statistical analysis was carried out by Me Nemar, Marginal Homogeneity and Wilcoxon tests.Results: The results revealed changes in nucleus and cytoplasm, and N/C ratio, formation of bizar cells, cellular abnormality, nucleous and cytoplasmic vacuolization in affected cells during treatment. There was statistically significant differences between the groups (p<0.001). Keratinization of basal cell mucosa in CYTOLOGY slide was observed after treatment (P<0.01) and also there was an increase in number of inflammatory cells (p<0.001). Cellular apoptosis, numerous granular cells with large size granules, cells with multiple nucleous and clear nuclei, bacterial colony and candida were observed after treatment.Conclusion: CHEMORADIOTHERAPymay induce formation of bizar cells, abnormal nucleous and cytoplasm, changes in N/C ratio, Cellular abnormality, and cellular vacuolization.

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APA: Copy

MASHHADI ABBAS, F., MIRZAEI, HAMID REZA, AKBARZADEH BAGHBAN, A.R., & RAZAVI, A.A.. (2008). MICROSCOPIC ASSESSMENT OF THE EFFECTS OF CHEMORADIOTHERAPY ON NORMAL ORAL MUCOSA IN PATIENTS WITH HEAD AND NECK CANCER. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, 26(3 (77)), 326-333. SID. https://sid.ir/paper/21811/en

Vancouver: Copy

MASHHADI ABBAS F., MIRZAEI HAMID REZA, AKBARZADEH BAGHBAN A.R., RAZAVI A.A.. MICROSCOPIC ASSESSMENT OF THE EFFECTS OF CHEMORADIOTHERAPY ON NORMAL ORAL MUCOSA IN PATIENTS WITH HEAD AND NECK CANCER. JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE[Internet]. 2008;26(3 (77)):326-333. Available from: https://sid.ir/paper/21811/en

IEEE: Copy

F. MASHHADI ABBAS, HAMID REZA MIRZAEI, A.R. AKBARZADEH BAGHBAN, and A.A. RAZAVI, “MICROSCOPIC ASSESSMENT OF THE EFFECTS OF CHEMORADIOTHERAPY ON NORMAL ORAL MUCOSA IN PATIENTS WITH HEAD AND NECK CANCER,” JOURNAL OF DENTAL SCHOOL SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCE, vol. 26, no. 3 (77), pp. 326–333, 2008, [Online]. Available: https://sid.ir/paper/21811/en

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