CONCOMITANT EFFECT OF AEROBIC TRAINING AND BARIGEH TURMERIC SUPPLEMENT ON CARDIAC PROTECTIVE SYSTEM CHANGES DURING NITRO-L ARGININE METHYL ESTER-INDUCED HYPERTENSION IN RATS

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DABIDI ROSHAN V.; FALLAH M.

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Journal: SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE) Year:2012 | Volume:4 | Issue:15 Page(s): 121-134

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Title

CONCOMITANT EFFECT OF AEROBIC TRAINING AND BARIGEH TURMERIC SUPPLEMENT ON CARDIAC PROTECTIVE SYSTEM CHANGES DURING NITRO-L ARGININE METHYL ESTER-INDUCED HYPERTENSION IN RATS

Author(s)

DABIDI ROSHAN V. | FALLAH M. | Issue Writer Certificate

Keywords

HYPERTENSIONQ2

AEROBIC EXERCISEQ2

ANTIOXIDANTQ2

CARDIOVASCULAR DISEASEQ3

APELINERGIC SYSTEMQ2

Abstract

Studies indicate Apelin is a vascular dilator peptide that plays an important role in regulating vascular tone and cardiovascular function, however, the effect of physical activity and ANTIOXIDANT supplement on apelin and its receptor is not clear. The aim of this study was to determine the effects of combined AEROBIC EXERCISE and barigeh (ferula gummosa boiss) supplement on the cardiac protective system (Apelin and its receptor) during Nitro-Larginine-methyl ester-induced HYPERTENSION. Forty male Wistar rats were randomly divided into 4 groups (Baseline, Sham-operate, L-NAME and combination of exercise and supplement groups. For the HYPERTENSION, LNAME is administrated with 10 mg/kg dosage, intraperitoneally (i.p), for 8 weeks and 5 sessions a week in L-NAME and exercise and supplement groups. Training protocol was performed 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks on treadmill. Ferula gummosa was administered with 0.9 g/kg per day dosage for 8 weeks using gavage. The results showed, administration of L-NAME led to HYPERTENSION, reduce in Apelin and its receptor (APJ) and angiotensin converting enzyme inhibitor (ACE-I), as compared to control groups (baseline and sham). The combination of AEROBIC EXERCISE+supplement cause inhibitor of the HYPERTENSION up-regulation following L-NAME administration. Moreover, it significantly increases the cardiac APELINERGIC SYSTEM and ACE-1, as compared to L-NAME, sham and control groups. The results of our study suggest non-pharmacological methods could be new approach for cardiac protection against HYPERTENSION-induced chronic stress.

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APA: Copy

DABIDI ROSHAN, V., & FALLAH, M.. (2012). CONCOMITANT EFFECT OF AEROBIC TRAINING AND BARIGEH TURMERIC SUPPLEMENT ON CARDIAC PROTECTIVE SYSTEM CHANGES DURING NITRO-L ARGININE METHYL ESTER-INDUCED HYPERTENSION IN RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), 4(15), 121-134. SID. https://sid.ir/paper/228251/en

Vancouver: Copy

DABIDI ROSHAN V., FALLAH M.. CONCOMITANT EFFECT OF AEROBIC TRAINING AND BARIGEH TURMERIC SUPPLEMENT ON CARDIAC PROTECTIVE SYSTEM CHANGES DURING NITRO-L ARGININE METHYL ESTER-INDUCED HYPERTENSION IN RATS. SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE)[Internet]. 2012;4(15):121-134. Available from: https://sid.ir/paper/228251/en

IEEE: Copy

V. DABIDI ROSHAN, and M. FALLAH, “CONCOMITANT EFFECT OF AEROBIC TRAINING AND BARIGEH TURMERIC SUPPLEMENT ON CARDIAC PROTECTIVE SYSTEM CHANGES DURING NITRO-L ARGININE METHYL ESTER-INDUCED HYPERTENSION IN RATS,” SPORT PHYSIOLOGY (RESEARCH ON SPORT SCIENCE), vol. 4, no. 15, pp. 121–134, 2012, [Online]. Available: https://sid.ir/paper/228251/en

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