THE EFFECT OF REGULAR ENDURANCE EXERCISES AND GALBANUM SUPPLEMENT ON VASCULAR FUNCTION DURING CHRONIC HYPERTENSION IN MALE WISTAR RATS

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JALALI ZOHREH; DABIDI ROSHAN VALIOLLAH

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Journal: Journal of Sport Biosciences Year:2014 | Volume:6 | Issue:1 Page(s): 95-113

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Title

THE EFFECT OF REGULAR ENDURANCE EXERCISES AND GALBANUM SUPPLEMENT ON VASCULAR FUNCTION DURING CHRONIC HYPERTENSION IN MALE WISTAR RATS

Author(s)

JALALI ZOHREH | DABIDI ROSHAN VALIOLLAH | Issue Writer Certificate

Keywords

ANTIOXIDANTQ2

ENDURANCE EXERCISEQ2

HYPERTENSIONQ2

NITRIC OXIDEQ2

VASCULAR FUNCTIONQ2

Abstract

Chronic inflammation is an integral part of cardiovascular diseases and HYPERTENSION is found to be associated with endothelial dysfunction. The aim of this study was to evaluate the effect of endurance training and galbanum supplement on parameters related to VASCULAR FUNCTION including endothelial selectin (E-selectin) and angiotensin converting enzyme inhibitor (ACE-I) as inflammatory and vasoconstriction factors and NITRIC OXIDE (NO) as a vasodilation factor during chronic HYPERTENSION induced by Nitro-L-arginine methyl ester (L-NAME) in male Wistar rats.48 male Wistar rats were randomly divided into six groups: 1. basic, 2. sham, 3. L-NAME, 4. endurance training, 5. galbanum and 6. training+ galbanum. Groups 3 to 6 received 10 mg/kg L-NAME solutions under peritoneal space five times a week for eight weeks. Also, rats in the sham group received saline under the same condition. Groups 4 and 6 were performed the endurance running protocol on a treadmill with the speed of 15 to 20 meters per minutes for 25 to 64 minutes, 5 times a week for 8 weeks. Groups 5 and 6 received 90 mg/kg galbanum solution using gavage 5 times a week for 8 weeks. Infusion of L-NAME led to HYPERTENSION which was detected by a significant decrease in ACE-I (P<0.00). Furthermore, HYPERTENSION was associated with increased Eselectin and decreased NO. The training protocol significantly reduced E-selectin (P<0.00) and significantly increased NO (P<0.04) in group 4 and consumption of galbanum significantly decreased E-selectin (P<0.00) in group 5 and the combination of training and galbanum significantly decreased E-selecting (P<0.00) and significantly increased NO (P<0.03) in group 6 compared to L-NAME group at P≤0.05. Chronic HYPERTENSION is associated with endothelial dysfunction and nonpharmacological strategies such as endurance training and galbanum ANTIOXIDANT supplement probably control HYPERTENSION through the improvement of vascular endothelial function.

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APA: Copy

JALALI, ZOHREH, & DABIDI ROSHAN, VALIOLLAH. (2014). THE EFFECT OF REGULAR ENDURANCE EXERCISES AND GALBANUM SUPPLEMENT ON VASCULAR FUNCTION DURING CHRONIC HYPERTENSION IN MALE WISTAR RATS. SPORT BIOSCIENCES (HARAKAT), 6(1), 95-113. SID. https://sid.ir/paper/159633/en

Vancouver: Copy

JALALI ZOHREH, DABIDI ROSHAN VALIOLLAH. THE EFFECT OF REGULAR ENDURANCE EXERCISES AND GALBANUM SUPPLEMENT ON VASCULAR FUNCTION DURING CHRONIC HYPERTENSION IN MALE WISTAR RATS. SPORT BIOSCIENCES (HARAKAT)[Internet]. 2014;6(1):95-113. Available from: https://sid.ir/paper/159633/en

IEEE: Copy

ZOHREH JALALI, and VALIOLLAH DABIDI ROSHAN, “THE EFFECT OF REGULAR ENDURANCE EXERCISES AND GALBANUM SUPPLEMENT ON VASCULAR FUNCTION DURING CHRONIC HYPERTENSION IN MALE WISTAR RATS,” SPORT BIOSCIENCES (HARAKAT), vol. 6, no. 1, pp. 95–113, 2014, [Online]. Available: https://sid.ir/paper/159633/en

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