PROTECTIVE EFFECT OF TRAMADOL ON LIVER FOLLOWING TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN WAR BATTLEFIELD

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JAHANSHAHI A.A.; SOTOUDEH A.

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Journal: Ebnesina Year:2014 | Volume:16 | Issue:3 (48) Page(s): 32-38

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Title

PROTECTIVE EFFECT OF TRAMADOL ON LIVER FOLLOWING TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN WAR BATTLEFIELD

Author(s)

JAHANSHAHI A.A. | SOTOUDEH A. | Issue Writer Certificate

Keywords

ISCHEMIA-REPERFUSION INJURIESQ3

TRAMADOLQ3

LIVERQ3

TOURNIQUETQ3

Abstract

Background: Although the TOURNIQUET has been using for hemostasis for the long time, LIVER dysfunctions following ISCHEMIA-REPERFUSION INJURIES are common. TRAMADOL hydrochloride is an opioid drug that decreases the inflammatory response. In this study, the effect of this drug on the LIVER following ISCHEMIA-REPERFUSION INJURIES of hind limb in the rat was evaluated.Materials and methods: A total of 30 male Wistar rats were divided into two groups with fifteen rats in each group. Ischemia-reperfusion condition has been formed through blocking the femoral artery for two hours occlusion and 24 hours reperfusion. An ischemia-reperfusion group (I/R) did not receive the drug, while the treatment group received the drug (20mg/kg) intravenously, immediately after reperfusion.Results: In I/R group the level of both alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were significantly increased compered to treatment group (P<0.05). Also, histopathological damage in LIVER tissue was significantly increased in I/R group compered to treatment group (P<0.05).Conclusion: TRAMADOL hydrochloride has LIVER protective effects against ISCHEMIA-REPERFUSION INJURIES which could use it to alleviate the ISCHEMIA-REPERFUSION INJURIES causing by TOURNIQUET.

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APA: Copy

JAHANSHAHI, A.A., & SOTOUDEH, A.. (2014). PROTECTIVE EFFECT OF TRAMADOL ON LIVER FOLLOWING TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN WAR BATTLEFIELD. EBNESINA, 16(3 (48)), 32-38. SID. https://sid.ir/paper/228670/en

Vancouver: Copy

JAHANSHAHI A.A., SOTOUDEH A.. PROTECTIVE EFFECT OF TRAMADOL ON LIVER FOLLOWING TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN WAR BATTLEFIELD. EBNESINA[Internet]. 2014;16(3 (48)):32-38. Available from: https://sid.ir/paper/228670/en

IEEE: Copy

A.A. JAHANSHAHI, and A. SOTOUDEH, “PROTECTIVE EFFECT OF TRAMADOL ON LIVER FOLLOWING TOURNIQUET-INDUCED ISCHEMIA-REPERFUSION INJURY IN WAR BATTLEFIELD,” EBNESINA, vol. 16, no. 3 (48), pp. 32–38, 2014, [Online]. Available: https://sid.ir/paper/228670/en

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