NORMAL RANGE OF VITAMIN D: RELATIONSHIP BETWEEN SERUM PTH AND BONE MINERAL DENSITY

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HOSSEINNEZHAD ARASH; PAZHOUHI M.; JAVADI E.; MAGHBOOLI Z.; MADANI F.S.; ARDESHIR LARIJANI MOHAMMAD BAGHER

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Journal: Payesh Year:2004 | Volume:3 | Issue:1 Page(s): 19-25

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Title

NORMAL RANGE OF VITAMIN D: RELATIONSHIP BETWEEN SERUM PTH AND BONE MINERAL DENSITY

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Keywords

VITAMIN DQ2

SERUM PTHQ2

BONE MINERAL DENSITYQ4

Abstract

Objective(s): To quantify the relationship between SERUM PTH, VITAMIN D and BONE MINERAL DENSITY to determine normal range of VITAMIN D in normal population.Methods: A total of 830 healthy individuals aged 30 to 76 years old (60.8% women, 39.2% men) living in Tehran were randomly selected, following exclusion of people suffering from endocrine, rheumatologic or chronic diseases, fractures, other conditions or using drugs that affecting bone metabolism. VITAMIN D and Ca intakes were assessed with a food frequency questionnaire. Self-reported daily time of sun exposure was used to categorize exposure to sunshine. All participants underwent clinical examination and lumbar spine and proximal of femur BMD by using dual-energy X-ray absorptiometry technique. Plasma level of 25(OH) D, Ca, Phosphate (P), Alkaline phosphates (ALK P), parathyroid hormone (PTH) measured during winter. The correlation between these results was investigated.Results: PTH correlated inversely with 25(OH)D .In multivariate analysis PTH correlated inversely with whole body BMD (mostly lumbar spine) but not with the hip BMD. No association was found between 25(OH) D levels and BMD at any site in univariate or multivariate analysis. Based on this relationship between PTH, VITAMIN D and BMD we obtained normal range of VITAMIN D. Cut -off point for sever VITAMIN D deficiency was lower than 18 nmol/l and range of moderate & mild were 18-23 & 23-36 nmol/l, respectively.Conclusion: Normal range determination of VITAMIN D based on relationship between PTH, VITAMIN D and BMD can be shown biological bone variation and is useful in prevention strategy.

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APA: Copy

HOSSEINNEZHAD, ARASH, PAZHOUHI, M., JAVADI, E., MAGHBOOLI, Z., MADANI, F.S., & ARDESHIR LARIJANI, MOHAMMAD BAGHER. (2004). NORMAL RANGE OF VITAMIN D: RELATIONSHIP BETWEEN SERUM PTH AND BONE MINERAL DENSITY. PAYESH, 3(1), 19-25. SID. https://sid.ir/paper/23539/en

Vancouver: Copy

HOSSEINNEZHAD ARASH, PAZHOUHI M., JAVADI E., MAGHBOOLI Z., MADANI F.S., ARDESHIR LARIJANI MOHAMMAD BAGHER. NORMAL RANGE OF VITAMIN D: RELATIONSHIP BETWEEN SERUM PTH AND BONE MINERAL DENSITY. PAYESH[Internet]. 2004;3(1):19-25. Available from: https://sid.ir/paper/23539/en

IEEE: Copy

ARASH HOSSEINNEZHAD, M. PAZHOUHI, E. JAVADI, Z. MAGHBOOLI, F.S. MADANI, and MOHAMMAD BAGHER ARDESHIR LARIJANI, “NORMAL RANGE OF VITAMIN D: RELATIONSHIP BETWEEN SERUM PTH AND BONE MINERAL DENSITY,” PAYESH, vol. 3, no. 1, pp. 19–25, 2004, [Online]. Available: https://sid.ir/paper/23539/en

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