MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT

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BAGHSHANI HASAN; GHODSI VAHIDE

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Journal: EXPERIMENTAL ANIMAL BIOLOGY Year:2017 | Volume:6 | Issue:1 (21) Page(s): 71-79

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Title

MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT

Author(s)

BAGHSHANI HASAN | GHODSI VAHIDE | Issue Writer Certificate

Keywords

CYANIDE POISONINGQ1

GARLICQ2

OXIDATIVE DAMAGEQ1

Abstract

Chronic cyanide intoxication hasbeen shown to induce damage in various tissues. In the present study the effects of chronic exposure to potassium cyanide (KCN) on some oxidative stress-related parameters as well as Modulatory effects of GARLIC powder were studied.18 male wistar rats were assigned into three groups, 6 in each group. Group 1 served as control group. Group 2 received cyanide (KCN, 500 mg/L) in drinking water for 42 days. Rats in Group 3 received water containing KCN (500 mg/L in drinking) and also were fed a diet containing 5% GARLIC powder for 42 days. Cyanide caused increase in malondialdehyde (MDA) concentartins in all studies tissues, although the increase was only significant (P<0.05) in kidney, heart and brain. Significant increase of protein carbonyls was also observed in liver and kidney following CYANIDE POISONING. GARLIC supplementation in group 3 effectively decreased the augmented levels of MDA in kidney and brain to the levels that were not significantly different from control group. Moreover, values of protein carbonyl groups was also decreased notably in liver and kidney of group 3 to the levels that were not significantly different from control group. Results of the present study show that GARLIC has modulatory effect on cyanide-induced oxidative stress damage in rat and could have therapeutic and prophylactic effects on CYANIDE POISONING.

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APA: Copy

BAGHSHANI, HASAN, & GHODSI, VAHIDE. (2017). MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT. EXPERIMENTAL ANIMAL BIOLOGY, 6(1 (21) ), 71-79. SID. https://sid.ir/paper/236130/en

Vancouver: Copy

BAGHSHANI HASAN, GHODSI VAHIDE. MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT. EXPERIMENTAL ANIMAL BIOLOGY[Internet]. 2017;6(1 (21) ):71-79. Available from: https://sid.ir/paper/236130/en

IEEE: Copy

HASAN BAGHSHANI, and VAHIDE GHODSI, “MODULATORY EFFECTS OF GARLIC POWDER ON CYANIDE-INDUCED OXIDATIVE STRESS IN SOME TISSUES OF RAT,” EXPERIMENTAL ANIMAL BIOLOGY, vol. 6, no. 1 (21) , pp. 71–79, 2017, [Online]. Available: https://sid.ir/paper/236130/en

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