SYNTHESIS OF 3-(3-BROMO-4-HYDROXYPHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLE

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EDJLALI LADAN; ASHRAFI PARISA

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Journal: THE APPLICATION OF CHEMISTRY IN ENVIRONMENT Year:2010 | Volume:1 | Issue:4 Page(s): 9-13

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Title

SYNTHESIS OF 3-(3-BROMO-4-HYDROXYPHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLE

Author(s)

EDJLALI LADAN | ASHRAFI PARISA | Issue Writer Certificate

Keywords

4-(5- HYDROXYL METHYL) ISOXAZOLE-3-YL) PHENOLQ2

3-(3-BROMO-4-HYDROXY PHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLEQ3

4-METHOXYBENZALDEIDOXIMEQ3

Abstract

Isoxazole compounds which have various pharmacological, biological and industrial applications. Especially these compounds show the antivirus activity. It has been proved that they are effective in cure Parkinson and Alzheimer disease. In present research four kinds of isoxazole and an oxime compound have been synthesized. At the first, 4-Methoxybenzaldehyde changed into 4-methoxybenzaldeidoxime (1) by increasing sodium hypochlorite to hydroxylamine hydrochloride in pyridine as a solvent, the compound 1 changed to nitrile oxide and [2+3] cycloaddition happened by using propargyl alcohol, as a result 3- (4- methoxy phenyl) isoxazole-5-yl) methanol (2) was prepared. At the rest of the research 4- (5- hydroxyl methyl) isoxazole-3-yl) phenol (3) was prepared by reaction of HBr and compound 2 and acetic acid. Also, 2-boromo-4- (5- (hydroxy methyl) isoxazole- 3-yl) phenol (4) was prepared by reaction of Br2 and compound 3 in CH2Cl2. In the final step compound (4) was added to Br2 and CH2Cl2, and 3- (3-bromo-4-hydroxy phenyl) -4-bromo-5-hydroxy methyl isoxazole (5) was prepared. The structures of synthesized compounds were confirmed by FT-IR and 1H NMR spectroscopies.

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APA: Copy

EDJLALI, LADAN, & ASHRAFI, PARISA. (2010). SYNTHESIS OF 3-(3-BROMO-4-HYDROXYPHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLE. THE APPLICATION OF CHEMISTRY IN ENVIRONMENT, 1(4), 9-13. SID. https://sid.ir/paper/236286/en

Vancouver: Copy

EDJLALI LADAN, ASHRAFI PARISA. SYNTHESIS OF 3-(3-BROMO-4-HYDROXYPHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLE. THE APPLICATION OF CHEMISTRY IN ENVIRONMENT[Internet]. 2010;1(4):9-13. Available from: https://sid.ir/paper/236286/en

IEEE: Copy

LADAN EDJLALI, and PARISA ASHRAFI, “SYNTHESIS OF 3-(3-BROMO-4-HYDROXYPHENYL)-4-BROMO-5-HYDROXY METHYL ISOXAZOLE,” THE APPLICATION OF CHEMISTRY IN ENVIRONMENT, vol. 1, no. 4, pp. 9–13, 2010, [Online]. Available: https://sid.ir/paper/236286/en

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