INVESTIGATE THE POSSIBILITY OF SYNTHESIS - N ((3-4 - CHLORO PHENYL ISOXAZOL)-5-YL) METHYL PNTANAMYD AS A NEW COMBINATION

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PARVIZI SHAHED; EDJLALI LADAN; BABAZADEH MIRZAAGHA; SOLEYMANI -

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Journal: THE APPLICATION OF CHEMISTRY IN ENVIRONMENT Year:2011 | Volume:2 | Issue:6 Page(s): 11-13

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Title

INVESTIGATE THE POSSIBILITY OF SYNTHESIS - N ((3-4 - CHLORO PHENYL ISOXAZOL)-5-YL) METHYL PNTANAMYD AS A NEW COMBINATION

Author(s)

PARVIZI SHAHED | EDJLALI LADAN | BABAZADEH MIRZAAGHA | SOLEYMANI - | Issue Writer Certificate

Keywords

ISOXAZOLESQ2

4-CHLORO BENZALDOXIMEQ2

PHARMACOLOGICALQ2

Abstract

Isoxazole compound which have various PHARMACOLOGICAL applications act as antivirus especially. It has been proved that they are effective on the cure of Parkinson and Alzheimer disease. In present research, two kinds of isoxazol and an oxime compound have been synthesized. 4-chloro benzaldehyde changed into 4-CHLORO BENZALDOXIME by increasing of sodium hypochlorite to hydroxylamine hydrochloride in pyridine as a solvent. The compound 1 changed to nitrile oxide and [3+2] cycloaddition happened by using propargyl alcohol. As a result 3-(4-chlorophenyl)-5-hydroxy methyl isoxazol was prepared. In final step, N-((3-(4-chlorophenyl) isoxazol-5-yl) Methyl) cyclopentanamine was prepared by reaction of PBr3 and C5H11N with compound (2).The structure of synthesized compounds were confirmed by FT-IR, 1H NMR spectroscopies.

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APA: Copy

PARVIZI, SHAHED, EDJLALI, LADAN, BABAZADEH, MIRZAAGHA, & SOLEYMANI, -. (2011). INVESTIGATE THE POSSIBILITY OF SYNTHESIS - N ((3-4 - CHLORO PHENYL ISOXAZOL)-5-YL) METHYL PNTANAMYD AS A NEW COMBINATION. THE APPLICATION OF CHEMISTRY IN ENVIRONMENT, 2(6), 11-13. SID. https://sid.ir/paper/236367/en

Vancouver: Copy

PARVIZI SHAHED, EDJLALI LADAN, BABAZADEH MIRZAAGHA, SOLEYMANI -. INVESTIGATE THE POSSIBILITY OF SYNTHESIS - N ((3-4 - CHLORO PHENYL ISOXAZOL)-5-YL) METHYL PNTANAMYD AS A NEW COMBINATION. THE APPLICATION OF CHEMISTRY IN ENVIRONMENT[Internet]. 2011;2(6):11-13. Available from: https://sid.ir/paper/236367/en

IEEE: Copy

SHAHED PARVIZI, LADAN EDJLALI, MIRZAAGHA BABAZADEH, and - SOLEYMANI, “INVESTIGATE THE POSSIBILITY OF SYNTHESIS - N ((3-4 - CHLORO PHENYL ISOXAZOL)-5-YL) METHYL PNTANAMYD AS A NEW COMBINATION,” THE APPLICATION OF CHEMISTRY IN ENVIRONMENT, vol. 2, no. 6, pp. 11–13, 2011, [Online]. Available: https://sid.ir/paper/236367/en

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