Pancreatic Cancer: From Genome to New Therapies

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Moshari M.; Jebelli A.

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Journal: SADRA MEDICAL SCIENCES JOURNAL Year:2019 | Volume:7 | Issue:2 Page(s): 211-224

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Information Journal Paper

Title

Pancreatic Cancer: From Genome to New Therapies

Author(s)

Moshari M. | Jebelli A. | Issue Writer Certificate

Keywords

Pancreatic cancerQ2

GeneticsQ2

Oncolytic VirusesQ1

CRISPRQ1

Abstract

Pancreatic cancer is ranked as the fourth leading cause of cancer related death. The survival rate of patients is very low and the mortality rate in men is higher than that of women. Various hereditary and non-hereditary factors are involved in the formation of Pancreatic cancer; one of the important non-hereditary factors is smoking. Besides, it is known that the risk of Pancreatic cancer in patients with diabetes mellitus is twice as high as in the non-diabetic population. Hereditary conditions also include genetic (activation of oncogenes and inactivation of tumor suppressor genes) and epigenetic changes (lncRNA). The mutation in KRAS oncogene is observed in 95% of the patients with Pancreatic cancer. Despite the common use of ultrasound and tumor markers in diagnosing Pancreatic cancer, their importance as powerful diagnostic tools has been challenged. An innovation in common therapeutic strategies such as chemotherapy, immunotherapy, and gene therapy based on genetic vectors has provided a promising tool for treatment. Using Oncolytic Viruses with selective proliferation in cancer cells and minimal adverse effects has opened a new perspective on the future of treatment of this cancer. In addition, novel technologies in gene editing including CRISPR have allowed the genome manipulation of cancer cells to identify and regulate the molecular pathways involved in Pancreatic cancer. Considering that multiple genetic and epigenetic changes play a role in the pathogenesis of this cancer, simultaneous control of these pathways with multiple therapies can be a useful therapeutic strategy for Pancreatic cancer.

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APA: Copy

Moshari, M., & Jebelli, A.. (2019). Pancreatic Cancer: From Genome to New Therapies. SADRA MEDICAL SCIENCES JOURNAL, 7(2 ), 211-224. SID. https://sid.ir/paper/238871/en

Vancouver: Copy

Moshari M., Jebelli A.. Pancreatic Cancer: From Genome to New Therapies. SADRA MEDICAL SCIENCES JOURNAL[Internet]. 2019;7(2 ):211-224. Available from: https://sid.ir/paper/238871/en

IEEE: Copy

M. Moshari, and A. Jebelli, “Pancreatic Cancer: From Genome to New Therapies,” SADRA MEDICAL SCIENCES JOURNAL, vol. 7, no. 2 , pp. 211–224, 2019, [Online]. Available: https://sid.ir/paper/238871/en

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