THE ROLE OF PERIPHERAL GLYCINE RECEPTORS IN CANNABINOID-INDUCED FEEDING

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAJINEZHAD MOHAMMAD REZA; JAMSHIDIAN ABBAS; AKBARI MOHAMMAD EBRAHIM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES Year:2017 | Volume:5 | Issue:1 Page(s): 57-63

Download Full-Text

Persian Verion

View:

950

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF PERIPHERAL GLYCINE RECEPTORS IN CANNABINOID-INDUCED FEEDING

Author(s)

HAJINEZHAD MOHAMMAD REZA | JAMSHIDIAN ABBAS | AKBARI MOHAMMAD EBRAHIM | Issue Writer Certificate

Keywords

CB1 CANNABINOID RECEPTORSQ1

RATSQ1

GLYCINE RECEPTORSQ1

Abstract

Background & Aim: Peripheral cannabinoid and GLYCINE RECEPTORS are involved in food intake regulation. This study was conducted to investigate the possible interaction between these two receptors in regulating food intake.Methods: This is an experimental study which was conducted on forty male Wistar RATS. In the first phase of the experiment, the RATS simultaneously received intraperitoneal injections of arachidonyl-2' -chloroethylamid (ACEA), CB1 cannabinoid receptor agonist (1 mg/kg) and glycine (100 mg/kg). In the second phase, the effect of intraperitoneal pretreatment with strychnine hydrochloride (post synaptic glycine receptor antagonist) with a dose of 0.01 mg/kg on ACEA, induced feeding was investigated. In the third phase, the impact of intraperitoneal pretreatment with AM281 with a dose of 0.5 mg/kg (CB1 receptor antagonist), glycine induced feeding behaviors was surveyed. Finally, in the fourth phase, the interaction effect of AM281 and strychnine hydrochloride was evaluated.Results: In the first step, intraperitoneal injection of glycine significantly increased food intake. Also, following the administration, food intake significantly increased (p˂0.05). Co-injection of glycine and ACEA had no significant effect on food intake compared to the sole injection of each agent (p˃0.05). In the second step, intraperitoneal pretreatment with strychnine hydrochloride had no significant effect on ACEA-induced hyperphagia. Furthermore, intraperitoneal pretreatment with AM281 did not affect glycine induced feeding. In the fourth phase, co-administration of AM281 and strychnine hydrochloride significantly decreased cumulative food intake compared to the sole administration of each agent (p˂0.05).Conclusion: The interaction between peripheral CB1 CANNABINOID RECEPTORS and GLYCINE RECEPTORS has not been investigated so far. In the present study, despite some synergistic effects, it seems that glycine and cannabinoid receptors can cause hyperphagia through independent neuronal pathways.

Cites

No record.

References

No record.

Cite

APA: Copy

HAJINEZHAD, MOHAMMAD REZA, JAMSHIDIAN, ABBAS, & AKBARI, MOHAMMAD EBRAHIM. (2017). THE ROLE OF PERIPHERAL GLYCINE RECEPTORS IN CANNABINOID-INDUCED FEEDING. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, 5(1 ), 57-63. SID. https://sid.ir/paper/244621/en

Vancouver: Copy

HAJINEZHAD MOHAMMAD REZA, JAMSHIDIAN ABBAS, AKBARI MOHAMMAD EBRAHIM. THE ROLE OF PERIPHERAL GLYCINE RECEPTORS IN CANNABINOID-INDUCED FEEDING. JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;5(1 ):57-63. Available from: https://sid.ir/paper/244621/en

IEEE: Copy

MOHAMMAD REZA HAJINEZHAD, ABBAS JAMSHIDIAN, and MOHAMMAD EBRAHIM AKBARI, “THE ROLE OF PERIPHERAL GLYCINE RECEPTORS IN CANNABINOID-INDUCED FEEDING,” JOURNAL OF TORBAT HEYDARIYEH UNIVERSITY OF MEDICAL SCIENCES, vol. 5, no. 1 , pp. 57–63, 2017, [Online]. Available: https://sid.ir/paper/244621/en

Related Journal Papers