THE INFLUENCE OF GL-9 PEPTIDE ON A549 AND HUMAN AND ANIMAL BLOOD CELLS

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HOOSHMAND K.; ASOODEH A.

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Journal: Journal of Molecular and Cellular Researches Year:2016 | Volume:29 | Issue:4 Page(s): 463-473

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Title

THE INFLUENCE OF GL-9 PEPTIDE ON A549 AND HUMAN AND ANIMAL BLOOD CELLS

Author(s)

HOOSHMAND K. | ASOODEH A. | Issue Writer Certificate

Keywords

GL-9 PEPTIDEQ1

A549 CELL LINEQ1

MTTQ2

HEMOLYTIC ACTIVITYQ1

DENSITY GRADIENT OF FICOL-HYPAQUEQ1

Abstract

Cancer has become an epidemic disease. Scientists are trying multiple methods of chemotherapy, radiotherapy and surgery to improve patient’s health. However, the use of these methods of treatment are associated with severe side effects, which make the treatment process very painful. Therefore, researches are looking for new treatment options with fewer side effects using natural compounds such as peptides. In this study, we used different concentrations of GL-9 PEPTIDE to evaluate its cytotoxic effect on human lung adenocarcinoma cells (A549) and normal human and bovine lymphocytes and erythrocytes cells was investigated. 12, 25 and 50 mg/ml of GL-9 PEPTIDE were used to examine its cytotoxic effect on human lung adenocarcinoma cells (A549) after 24 h and 48 h via MTT assay. Furthermore, hemolysis and lympho-toxic assay were used to analyze GL-9 cytotoxic influence on human normal cells. Our results showed the cytotoxic effect of GL-9 PEPTIDE on A549 CELL LINE within 48 h. Moreover, our results showed no hemolytic and cytotoxic effect on human and bovine red and white blood cells. GL-9 PEPTIDE had cytotoxic effect on A549 CELL LINE after 48h with no toxic activity on human and bovine peripheral blood mononuclear cells (PBMC), therefore through further analysis and examination this peptide could be a replace for common cancer therapy drugs in the near future.

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APA: Copy

HOOSHMAND, K., & ASOODEH, A.. (2016). THE INFLUENCE OF GL-9 PEPTIDE ON A549 AND HUMAN AND ANIMAL BLOOD CELLS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 29(4 ), 463-473. SID. https://sid.ir/paper/248546/en

Vancouver: Copy

HOOSHMAND K., ASOODEH A.. THE INFLUENCE OF GL-9 PEPTIDE ON A549 AND HUMAN AND ANIMAL BLOOD CELLS. JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2016;29(4 ):463-473. Available from: https://sid.ir/paper/248546/en

IEEE: Copy

K. HOOSHMAND, and A. ASOODEH, “THE INFLUENCE OF GL-9 PEPTIDE ON A549 AND HUMAN AND ANIMAL BLOOD CELLS,” JOURNAL OF MOLECULAR AND CELLULAR RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 29, no. 4 , pp. 463–473, 2016, [Online]. Available: https://sid.ir/paper/248546/en

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