EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION IN TYPE 1 DIABETIC RAT

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ABEDINZADEH M.; RASTGAR K.; ZARIFKAR ASAD ELAH; RAFATI ALI; MONABATI A.; KHAKPOUR B.

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Journal: JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES Year:2009 | Volume:18 | Issue:71 Page(s): 7-12

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Title

EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION IN TYPE 1 DIABETIC RAT

Author(s)

Keywords

C-PEPTIDEQ3

COGNITION DISORDERSQ3

DIABETES MELLITUSQ2

TYPE 1Q2

Abstract

Introduction: DIABETES MELLITUS is a common metabolic disorder that associates with structural and functional changes in central and peripheral nervous system and progressive decline in cognitive abilities. Recent experimental and clinical data suggested that C-PEPTIDE replacement during TYPE 1 diabetes exerts beneficial effects on diabetic rats.Objective: Determine the effect of intraperitoneal (IP) injection of C-PEPTIDE on cognitive dysfunction in TYPE 1 diabetic rats. Materials and Methods: 24 male Sprague dawly rats (230-300 gr) used for this project divided into 3 groups: 1. control group, 2. TYPE 1 diabetic group and 3. Diabetic group that receive C-PEPTIDE (25 nmol/kg/daily for 28 day/IP). Diabetes induced with IV injection of Streptozotocin (60mg/kg). Twenty one days after onset of diabet, behavioral tests conducted for seven days. Results: In reference memory assessment, the latency of finding platform during four days decline significantly in all groups (P<0.05). Mean escape time in diabetic group was significantly longer in comparison to other groups (P<0.05) but in comparison to diabetic group with C-PEPTIDE group, memory impairement decline significantly (P< 0.05).During three days of working memory test, the latency required for finding platform decreased significantly (P<0.05) but this time was longer in diabetic group (P<0.05). C-PEPTIDE could improve memory in diabetic group. Conclusion: C-PEPTIDE had significant role in control and inhibition of memory disorder progression.

Cites

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APA: Copy

ABEDINZADEH, M., RASTGAR, K., ZARIFKAR, ASAD ELAH, RAFATI, ALI, MONABATI, A., & KHAKPOUR, B.. (2009). EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION IN TYPE 1 DIABETIC RAT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, 18(71), 7-12. SID. https://sid.ir/paper/40082/en

Vancouver: Copy

ABEDINZADEH M., RASTGAR K., ZARIFKAR ASAD ELAH, RAFATI ALI, MONABATI A., KHAKPOUR B.. EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION IN TYPE 1 DIABETIC RAT. JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;18(71):7-12. Available from: https://sid.ir/paper/40082/en

IEEE: Copy

M. ABEDINZADEH, K. RASTGAR, ASAD ELAH ZARIFKAR, ALI RAFATI, A. MONABATI, and B. KHAKPOUR, “EFFECT OF C-PEPTIDE ON COGNITIVE DYSFUNCTION IN TYPE 1 DIABETIC RAT,” JOURNAL OF GUILAN UNIVERSITY OF MEDICAL SCIENCES, vol. 18, no. 71, pp. 7–12, 2009, [Online]. Available: https://sid.ir/paper/40082/en

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