APOPTOSIS OF GINGIVAL CONNECTIVE TISSUE CELLS IN DIABETIC INDIVIDUALS WITH CHRONIC PERIODONTITIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KIANI YAZDY FARIN; GOLSHAH MASOUD; RAZMKHAH MAHBOOBEH; GHADERY ABBAS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Dental Medicine Year:2013 | Volume:26 | Issue:2 (75) Page(s): 99-107

Download Full-Text

Persian Verion

View:

858

Download:

Cites:

Information Journal Paper

Title

APOPTOSIS OF GINGIVAL CONNECTIVE TISSUE CELLS IN DIABETIC INDIVIDUALS WITH CHRONIC PERIODONTITIS

Author(s)

KIANI YAZDY FARIN | GOLSHAH MASOUD | RAZMKHAH MAHBOOBEH | GHADERY ABBAS | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ2

APOPTOSISQ2

CHRONIC PERIODONTITISQ2

REAL-TIME PCRQ2

Abstract

Background and Aims: APOPTOSIS or programmed cell death plays an important role in the pathogenesis of many diseases. Previous studies suggest that APOPTOSIS is involved in the pathogenesis of periodontal disease. On the other hand, it is also suggested that DIABETES MELLITUS enhances APOPTOSIS of connective tissue cells. Thus, we measured expression of proteins which are relevant to APOPTOSIS in the gingival tissue of diabetic patients with CHRONIC PERIODONTITIS in comparison to non diabetic individuals.Materials and Methods: 25 patients with diabetes and CHRONIC PERIODONTITIS and 16 non diabetic controls with CHRONIC PERIODONTITIS were included in this study. 4 weeks after scaling and root planning and oral hygiene instructions, periodontal surgery was done and gingival tissues obtained during surgery, were sent to lab to investigate expression of Fas, P53, Bcl-2 and Survivin using REAL-TIME PCR technique. Data were analyzed using Mann-Whitney and Chi-squared.Results: Pro-apoptotic proteins (Fas, P53) were significantly (P<0.05) higher in gingival tissues of diabetics (9.5×10-6, 2.4×10-6, respectively) in comparison to non diabetics (9.4×10-7, 5.6×10-7), whereas the difference in expression of anti-apoptotic proteins (Bcl-2, Survivin) between 2 groups was not significant (9.7×10-8, 3.5×10-7 in comparison to 1.4×10-7, 3.1×10-7, respectively) (P=0.91, P=0.29 respectively).Conclusion: APOPTOSIS was increased in gingival connective tissue of diabetic patients with CHRONIC PERIODONTITIS in comparison with non diabetic ones. Therefore, intervention in expression or function of pro-apoptotic proteins (Fas, P53) could be a new goal in the treatment of periodontal disease of diabetic patients.

Cites

No record.

References

No record.

Cite

APA: Copy

KIANI YAZDY, FARIN, GOLSHAH, MASOUD, RAZMKHAH, MAHBOOBEH, & GHADERY, ABBAS. (2013). APOPTOSIS OF GINGIVAL CONNECTIVE TISSUE CELLS IN DIABETIC INDIVIDUALS WITH CHRONIC PERIODONTITIS. JOURNAL OF DENTAL MEDICINE, 26(2 (75)), 99-107. SID. https://sid.ir/paper/25588/en

Vancouver: Copy

KIANI YAZDY FARIN, GOLSHAH MASOUD, RAZMKHAH MAHBOOBEH, GHADERY ABBAS. APOPTOSIS OF GINGIVAL CONNECTIVE TISSUE CELLS IN DIABETIC INDIVIDUALS WITH CHRONIC PERIODONTITIS. JOURNAL OF DENTAL MEDICINE[Internet]. 2013;26(2 (75)):99-107. Available from: https://sid.ir/paper/25588/en

IEEE: Copy

FARIN KIANI YAZDY, MASOUD GOLSHAH, MAHBOOBEH RAZMKHAH, and ABBAS GHADERY, “APOPTOSIS OF GINGIVAL CONNECTIVE TISSUE CELLS IN DIABETIC INDIVIDUALS WITH CHRONIC PERIODONTITIS,” JOURNAL OF DENTAL MEDICINE, vol. 26, no. 2 (75), pp. 99–107, 2013, [Online]. Available: https://sid.ir/paper/25588/en

Related Journal Papers