EVALUATION OF ANTIOXIDANT AND PROTECTIVE EFFECTS OF DRACOCEPHALUM MOLDAVICA EXTRACT ON BETA-AMYLOID PEPTIDE-INDUCED TOXICITY IN PC12 CELLS

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EMRANI SHOKUFE; ZHIANI RAHELE; Dolatabadi Samaneh

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:3 Page(s): 54-63

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Title

EVALUATION OF ANTIOXIDANT AND PROTECTIVE EFFECTS OF DRACOCEPHALUM MOLDAVICA EXTRACT ON BETA-AMYLOID PEPTIDE-INDUCED TOXICITY IN PC12 CELLS

Author(s)

EMRANI SHOKUFE | ZHIANI RAHELE | Dolatabadi Samaneh | Issue Writer Certificate

Keywords

ALZHEIMER DISEASEQ2

AMYLOID BETA-PEPTIDESQ3

OXIDATIVE STRESSQ2

PC12 CELLSQ3

Abstract

Introduction: Excessive accumulation of beta-amyliod peptide, the major component of senile plaques in ALZHEIMER DISEASE (AD), causes neuronal death through induction of OXIDATIVE STRESS.The medicinal plants from the Lamiaceae family contain the antioxidant activity. Moreover, neuroprotective properties of other species of this family have been reported.Materials and Methods: Aerial parts of the plants were extracted with ethanol and water using maceration method. Antioxidant activity of the extract was evaluated by 2, 2-diphenyl-1-picrylhydrazyl radical scavenging. PC12 CELLS were incubated with different concentrations of the extract in culture medium 1h prior to incubation with amyloid beta peptide. Cell toxicity and biomarkers of OXIDATIVE STRESS were assessed 24h after addition of amyloid beta peptide by MTT assay.Results: Butylated hydroxytoluene (BHT) at concentrations of 0.01, 0.1, and 1 mg/ml had higher antiradical activity than Dracocephalum moldavica extract. However, at higher concentrations, plant extract showed a higher anti-radical activity than BHT. The plant extract at the concentration range of 0.01-100 mg/ml did not show any toxic effect on PC12 CELLS. The plant extract at concentrations of 1, 10, and 100 mg/ml protected cells against beta amyloid toxicity and at concentration of 10 mg/ml was able to prevent biomarkers changes of OXIDATIVE STRESS induced by beta amyloid.Conclusion: The extract of Dracocephalum moldavica prevents the toxicity of amyloid beta peptide by inhibiting the OXIDATIVE STRESS pathways and may useful in the treatment of AD.

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APA: Copy

EMRANI, SHOKUFE, ZHIANI, RAHELE, & Dolatabadi, Samaneh. (2015). EVALUATION OF ANTIOXIDANT AND PROTECTIVE EFFECTS OF DRACOCEPHALUM MOLDAVICA EXTRACT ON BETA-AMYLOID PEPTIDE-INDUCED TOXICITY IN PC12 CELLS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(3), 54-63. SID. https://sid.ir/paper/257901/en

Vancouver: Copy

EMRANI SHOKUFE, ZHIANI RAHELE, Dolatabadi Samaneh. EVALUATION OF ANTIOXIDANT AND PROTECTIVE EFFECTS OF DRACOCEPHALUM MOLDAVICA EXTRACT ON BETA-AMYLOID PEPTIDE-INDUCED TOXICITY IN PC12 CELLS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(3):54-63. Available from: https://sid.ir/paper/257901/en

IEEE: Copy

SHOKUFE EMRANI, RAHELE ZHIANI, and Samaneh Dolatabadi, “EVALUATION OF ANTIOXIDANT AND PROTECTIVE EFFECTS OF DRACOCEPHALUM MOLDAVICA EXTRACT ON BETA-AMYLOID PEPTIDE-INDUCED TOXICITY IN PC12 CELLS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 3, pp. 54–63, 2015, [Online]. Available: https://sid.ir/paper/257901/en

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