PHYLOGENETIC STUDY OF GABAA RECEPTORS IN HUMAN AND RAT SPECIES: EVALUATION OF FAMILY RELATIONSHIP

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HASHEMI ZAHRASADAT; ESHAGHABADI AREZOU; ALIPOUR FATEMEH; JAFARIAN MARYAM; MODARRES MOUSAVI SAYED MOSTAFA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:3 Page(s): 65-69

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Title

PHYLOGENETIC STUDY OF GABAA RECEPTORS IN HUMAN AND RAT SPECIES: EVALUATION OF FAMILY RELATIONSHIP

Author(s)

Keywords

GAMMA-AMINOBUTYRIC ACIDQ3

FAMILY RELATIONSQ2

BRAINQ2

Abstract

Introduction: An effort to establish phylogenetic values for the major GAMMA-AMINOBUTYRIC ACID A (GABAA) receptor subunit mRNAs a, b, g, d, e, q, p could be improved our knowledge on their classification and function. In addition, the similarities and divergences between different species can be important to determine the function of these receptors.Materials and Methods: After alignment of mRNA complete gene sequences of GABAA subunits in homosapinse and rattus norvegicus species, the phylogenetic tree were constructed with CLC Main Workbench 5.5 software.Results: The results revealed highly similarities between GABAA subunits of homosapience and rattus norvegicus. In addition, these findings illustrated some divergences between b1, b2, b3, g1, g2, e and q subunits with other subunits.Conclusion: The similarities and divergences among various GABAA subunits may be an important cause of different distribution and function of GABAA subunits in different region of the central nervous system.

Cites

PHYLOGENETIC STUDY OF ALPHA SUBUNITS OF GABAA RECEPTOR BETWEEN HUMAN AND RAT

References

SUBUNITS OF GAMMA-AMINOBUTYRIC ACID RECEPTORS AND THEIR ROLES IN NEUROPSYCHOLOGICAL DISORDERS

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APA: Copy

HASHEMI, ZAHRASADAT, ESHAGHABADI, AREZOU, ALIPOUR, FATEMEH, JAFARIAN, MARYAM, & MODARRES MOUSAVI, SAYED MOSTAFA. (2016). PHYLOGENETIC STUDY OF GABA_A RECEPTORS IN HUMAN AND RAT SPECIES: EVALUATION OF FAMILY RELATIONSHIP. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(3), 65-69. SID. https://sid.ir/paper/257918/en

Vancouver: Copy

HASHEMI ZAHRASADAT, ESHAGHABADI AREZOU, ALIPOUR FATEMEH, JAFARIAN MARYAM, MODARRES MOUSAVI SAYED MOSTAFA. PHYLOGENETIC STUDY OF GABA_A RECEPTORS IN HUMAN AND RAT SPECIES: EVALUATION OF FAMILY RELATIONSHIP. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(3):65-69. Available from: https://sid.ir/paper/257918/en

IEEE: Copy

ZAHRASADAT HASHEMI, AREZOU ESHAGHABADI, FATEMEH ALIPOUR, MARYAM JAFARIAN, and SAYED MOSTAFA MODARRES MOUSAVI, “PHYLOGENETIC STUDY OF GABA_A RECEPTORS IN HUMAN AND RAT SPECIES: EVALUATION OF FAMILY RELATIONSHIP,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 3, pp. 65–69, 2016, [Online]. Available: https://sid.ir/paper/257918/en

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