Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine-Induced Model of Parkinson’ s Disease

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Nikokalam Nazif Neda; KHOSRAVI MARYAM; AHMADI RAMESH; BANANEJ MARYAM; MAJD AHMAD

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:8 | Issue:1 Page(s): 1-10

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

531

Download:

Cites:

Information Journal Paper

Title

Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine-Induced Model of Parkinson’ s Disease

Author(s)

Keywords

Methyl-4-phenyl-1Q1

2Q1

3Q1

6-tetrahydropyridineQ1

QuercetinQ1

MiceQ2

Abstract

Introduction: Parkinson’ s disease (PD) is a common neuropathological disorder caused by degeneration of dopaminergic neurons in the subs tantia nigra pars compacta. Quercetin (SNPC) is a compound with both anti-inflammatory and anti-oxidant effects, which can cross the blood brain barrier. The aim of the present s tudy was to evaluate neuroprotective effect of Quercetin in 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-induced model of PD in male Mice. Materials and Methods: 48 male NMRI Mice were divided into 6 groups (n=8); control, saline, MPTP, MPTP+ 20mg/kg Quercetin, MPTP+ 25mg/kg Quercetin, and MPTP+ 30mg/kg Quercetin. To induce PD model, MPTP (25mg/ Kg) was injected intraperitoneally (i. e. ) for 4 day. Catalepsy tes t was assessed by tes t bars one and 21 days after the las t injection MPTP. Quercetin (20, 25, 30mg/kg/day) was applied orally for 21 days. Dopaminergic neurons of SNPC were determined by immunohis tochemical labeling. The levels of interleukin 10 and TNF-α were determined in the subs tantia nigra and the s triatum using ELISA technique. Results: Treatment with Quercetin was significantly improved catalepsy. Furthermore, Quercetin significantly enhanced the number of neurons in SNPC, increased interleukin 10 protein levels, and reduced TNF-α protein values. Conclusion: Quercetin may exert a neuroprotective effect on progressive cell damage and the neuronal death in the subs tantia nigra in PD; possibly via modulation of inflammatory mediators.

Cites

No record.

References

No record.

Cite

APA: Copy

Nikokalam Nazif, Neda, KHOSRAVI, MARYAM, AHMADI, RAMESH, BANANEJ, MARYAM, & MAJD, AHMAD. (2020). Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine-Induced Model of Parkinson’ s Disease. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 8(1 ), 1-10. SID. https://sid.ir/paper/257946/en

Vancouver: Copy

Nikokalam Nazif Neda, KHOSRAVI MARYAM, AHMADI RAMESH, BANANEJ MARYAM, MAJD AHMAD. Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine-Induced Model of Parkinson’ s Disease. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2020;8(1 ):1-10. Available from: https://sid.ir/paper/257946/en

IEEE: Copy

Neda Nikokalam Nazif, MARYAM KHOSRAVI, RAMESH AHMADI, MARYAM BANANEJ, and AHMAD MAJD, “Neuroprotective Effect of Quercetin in 1-Methyl-4-Phenyl-1, 2, 3, 6-Tetrahydropyridine-Induced Model of Parkinson’ s Disease,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 8, no. 1 , pp. 1–10, 2020, [Online]. Available: https://sid.ir/paper/257946/en

Related Journal Papers