Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments

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Sasan Hosseinali; Samareh Gholami Azadeh; Hashemabadi Mohammad

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Journal: Neuroscience Journal of Shefaye Khatam Year:2019 | Volume:7 | Issue:4 Page(s): 23-29

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Information Journal Paper

Title

Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments

Author(s)

Sasan Hosseinali | Samareh Gholami Azadeh | Hashemabadi Mohammad | Issue Writer Certificate

Keywords

Alzheimer DiseaseQ2

TherapeuticsQ1

Gene ExpressionQ2

ExerciseQ2

MorphineQ1

Abstract

Introduction Alzheimer's disease is a progressive brain disorder, which slowly eliminates memory and intellectual ability and eventually destroys the ability to carry out the simple tasks. β amyloid plaque and neurofibrillary tangles are two important signatures of this disease, which caused by mutant in Tau, BACE1, and APP genes. They could be important targets for treatment of Alzheimer's disease. Materials and Methods Twenty-eight adult male Wistar rats weighing 180-240 g were classified into four groups, including control, Morphine treatment, Exercise treatment, and both Morphine and Exercise groups. After RNA extraction from hippocampal tissues and cDNA synthesis, Real time PCR for evaluation of different expressions of BACE1 and APP genes were performed. Results Data revealed that the expressions of BACE1 and APP significantly decreased during Morphine and Exercise treatment. Conclusion The present study suggests the possible role of Morphine and Exercise in treatment of Alzheimer's disease, possibly due to down-regulation of BACE1 and APP.

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APA: Copy

Sasan, Hosseinali, Samareh Gholami, Azadeh, & Hashemabadi, Mohammad. (2019). Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(4 ), 23-29. SID. https://sid.ir/paper/257960/en

Vancouver: Copy

Sasan Hosseinali, Samareh Gholami Azadeh, Hashemabadi Mohammad. Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(4 ):23-29. Available from: https://sid.ir/paper/257960/en

IEEE: Copy

Hosseinali Sasan, Azadeh Samareh Gholami, and Mohammad Hashemabadi, “Alteration in the Expression of Alzheimer's-Related Genes in Rat Hippocampus by Exercise and Morphine Treatments,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 4 , pp. 23–29, 2019, [Online]. Available: https://sid.ir/paper/257960/en

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