THE EFFECTS OF VERAPAMIL AND ETHOSUXIMIDE ON THE BRAIN BIOELECTRICAL ACTIVITY OF WAG/RIJ RATS

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SADIGHI ALVANDI MINA; SHAHABI PARVIZ; GHAMKHARI NEJAD GHAZALEH; Hosseinpour Mina; Foolad Forough

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Journal: Neuroscience Journal of Shefaye Khatam Year:2015 | Volume:3 | Issue:2 Page(s): 11-18

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Title

THE EFFECTS OF VERAPAMIL AND ETHOSUXIMIDE ON THE BRAIN BIOELECTRICAL ACTIVITY OF WAG/RIJ RATS

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Keywords

EPILEPSYQ3

ABSENCEQ2

BRAIN WAVESQ2

RATSQ3

VERAPAMILQ3

ETHOSUXIMIDEQ3

Abstract

Introduction: Synchronization of bioelectrical activities of neurons contributes to the initiation of epileptiform activities occurred during a seizure attack. ABSENCE seizures are characterized by synchronous and symmetric 2.5-4 Hz spike-wave discharges in children under 15 years old.More than half of children with ABSENCE EPILEPSY suffer from cognitive, education, and learning difficulties. The amplitude ratio of the theta and alpha waves is a reliable indicator for measuring of learning difficulties in children. The aim of this study was to evaluate the effect of L- and T-type voltage-dependent calcium channel blockers, VERAPAMIL and ETHOSUXIMIDE, on the amplitude of electroencephalogram (EEG) waves in WAG/Rij RATS, a genetic animal model of ABSENCE EPILEPSY.Materials and Methods: 18 adult WAG/Rij RATS in the age between 4 and 6 months were divided randomly into 3 groups. Using stereotaxic method, cannula was implanted in the peri-oral region of the primary somatosensory cortex for injection of drugs and recording electrodes were placed in the frontal and the occipital cortices. Electroencephalography was recorded 30 minutes before and one hour after drug injection.Results: The power of EEG sub-bands significantly decreased in the first 30 minutes after injection of VERAPAMIL and ETHOSUXIMIDE compared to the control group.Conclusion: Our data show that VERAPAMIL and ETHOSUXIMIDE can decrease the power of EEG sub-bands. However, they have not noticeable effect on theta to alpha ratio.

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APA: Copy

SADIGHI ALVANDI, MINA, SHAHABI, PARVIZ, GHAMKHARI NEJAD, GHAZALEH, Hosseinpour, Mina, & Foolad, Forough. (2015). THE EFFECTS OF VERAPAMIL AND ETHOSUXIMIDE ON THE BRAIN BIOELECTRICAL ACTIVITY OF WAG/RIJ RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 3(2), 11-18. SID. https://sid.ir/paper/258024/en

Vancouver: Copy

SADIGHI ALVANDI MINA, SHAHABI PARVIZ, GHAMKHARI NEJAD GHAZALEH, Hosseinpour Mina, Foolad Forough. THE EFFECTS OF VERAPAMIL AND ETHOSUXIMIDE ON THE BRAIN BIOELECTRICAL ACTIVITY OF WAG/RIJ RATS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2015;3(2):11-18. Available from: https://sid.ir/paper/258024/en

IEEE: Copy

MINA SADIGHI ALVANDI, PARVIZ SHAHABI, GHAZALEH GHAMKHARI NEJAD, Mina Hosseinpour, and Forough Foolad, “THE EFFECTS OF VERAPAMIL AND ETHOSUXIMIDE ON THE BRAIN BIOELECTRICAL ACTIVITY OF WAG/RIJ RATS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 3, no. 2, pp. 11–18, 2015, [Online]. Available: https://sid.ir/paper/258024/en

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