Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach

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Alavi Seyed Mojtaba; MIRZAEI AMIN; EBRAHIMPOUR REZA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2019 | Volume:7 | Issue:1 Page(s): 1-12

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Title

Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach

Author(s)

Alavi Seyed Mojtaba | MIRZAEI AMIN | EBRAHIMPOUR REZA | Issue Writer Certificate

Keywords

Basal GangliaQ2

Subthalamic NucleusQ2

Deep Brain StimulationQ2

Abstract

Introduction: The Basal Ganglia are subcortical s tructures of the brain which are involved in the motor sys tem. One of the common disorders related to malfunctioning of the Basal Ganglia is Parkinson’ s disease (PD). PD is accompanied by s trong and permanent beta band oscillations in the Basal Ganglia. Deep brain s timulation (DBS) of the Subthalamic Nucleus (STN) in the Basal Ganglia is known as an approach to reduce pathological beta oscillations in PD and to improve PD-related motor symptoms. Despite the success of this approach, its underlying mechanisms are s till unclear. Materials and Methods: In this s tudy, we proposed a computational network model for the cortico-Basal Ganglia loop based on the model sugges ted by Terman and colleagues earlier. We modified the network model in the manner that it can generate pathological beta oscillations in the PD s tate. Then, by applying different DBS scenarios (such as regular and irregular high frequency excitation of STN), we inves tigated which scenario is able to reduce the pathological beta power more efficiently. Results: Our results show that the network model can generate pathological beta band oscillations similar to what has experimentally been observed in the PD s tate. Our simulation results indicate that the regular DBS outperforms the irregular DBS, in terms of reducing the PD-related beta oscillations and improving the motor symptoms. Conclusion: Using our simulation results, we conclude that applying regular high frequency DBS on the STN neurons in the Basal Ganglia can ameliorate PD-related motor deficits better than irregular DBS pulses. This simulation result is experimentally tes table.

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APA: Copy

Alavi, Seyed Mojtaba, MIRZAEI, AMIN, & EBRAHIMPOUR, REZA. (2019). Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(1 ), 1-12. SID. https://sid.ir/paper/258031/en

Vancouver: Copy

Alavi Seyed Mojtaba, MIRZAEI AMIN, EBRAHIMPOUR REZA. Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(1 ):1-12. Available from: https://sid.ir/paper/258031/en

IEEE: Copy

Seyed Mojtaba Alavi, AMIN MIRZAEI, and REZA EBRAHIMPOUR, “Effects of Regular and Irregular Deep Brain Stimulation on the Basal Ganglia Dynamics: A Computational Approach,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 1 , pp. 1–12, 2019, [Online]. Available: https://sid.ir/paper/258031/en

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