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Information Journal Paper

Title

Disruption of the Brain Res ting State Networks in Parkinsonism

Pages

  23-33

Abstract

 Introduction: In the recent years, neuroimaging research on functional Magnetic Resonance Imaging (fMRI) is used in many pathological and mental conditions. The analysis of alterations in the res ting s tate networks (RSN) is an important method for the scrupulous unders tanding of the function and connectivity changes of the disease in order to provide new diagnos tic and therapeutic approaches. In this paper, we s tudied the res ting-s tate functional MRI (RsfMRI) data in Parkinson’ s disease (PD) to explore the complex disruption in the RSNs and the functional interactions between them. Materials and Methods: A total Rs-fMRI data of 10 Parkinsonism and 10 healthy people in the 3T-MRI sys tem were considered. Probabilis tic independent component analysis (PICA) was used to extract network components. RSNs were identified using spatial correlation with a res t reference template network. Dual regression and randomize technique calculated individual differences between the groups. Results: Group component maps resulted in some main clus ters of RSN that significantly overlapped with the reference network, such as the visual cortex, salience network, and supplementary motor area. Individual differences between RSN maps identified temporal, salience and cingulate networks as the main clus ters. Conclusion: Mos t of the previous s tudies inves tigated the functional connectivity alterations in PD by seed-based analysis. Here, we employed the datadriven approach based on group PICA to extract and evaluate RSN changes in all related neural networks. Our finding indicates that changes of the functional architecture of the RSNs are associated with PD.

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    APA: Copy

    GHASEMI, MAHDIEH, & Foroutannia, Ali. (2019). Disruption of the Brain Res ting State Networks in Parkinsonism. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(1 ), 23-33. SID. https://sid.ir/paper/258033/en

    Vancouver: Copy

    GHASEMI MAHDIEH, Foroutannia Ali. Disruption of the Brain Res ting State Networks in Parkinsonism. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(1 ):23-33. Available from: https://sid.ir/paper/258033/en

    IEEE: Copy

    MAHDIEH GHASEMI, and Ali Foroutannia, “Disruption of the Brain Res ting State Networks in Parkinsonism,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 1 , pp. 23–33, 2019, [Online]. Available: https://sid.ir/paper/258033/en

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