Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring

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SABAGHI AYOOB; HEYRANI ALI; KIANI AMIR; YOUSOFVAND NAMDAR

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Journal: Neuroscience Journal of Shefaye Khatam Year:2019 | Volume:7 | Issue:1 Page(s): 43-50

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Title

Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring

Author(s)

SABAGHI AYOOB | HEYRANI ALI | KIANI AMIR | YOUSOFVAND NAMDAR | Issue Writer Certificate

Keywords

SeizuresQ2

PregnancyQ1

MiceQ2

Glial Cell Line-Derived Neurotrophic FactorQ2

Abstract

Introduction: Epilepsy is a neurodevelopmental disorder and prenatal factors exert a profound influence on the development of the nervous sys tem in the offspring. Therefore, this s tudy was designed to inves tigate the effect of seizure during Pregnancy on pentylenetetrazol (PTZ)-induced seizure-like behavior in adult male Mice offspring. Materials and Methods: After Pregnancy, Mice were classified as: i) naive group; ii) seizure group, induction of seizure between the fourteenth and nineteenth days of Pregnancy by application of PTZ; iii) sham group, received normal saline intraperitoneally during the fourteenth and nineteenth days of Pregnancy; and iv) control group, pregnant Mice without injection during Pregnancy. At pos tnatal day 95, serum glial cell-derived neurotrophic factor (GDNF) levels and seizure susceptibility to PTZ in male offspring of all groups were evaluated. Results: The results showed that serum GDNF levels and seizure severity of offspring of Mice in the seizure group were significantly higher than male offspring in the other group. Conclusion: The present findings showed that seizure during Pregnancy may enhance seizure susceptibility in adult male offspring, possibly via increasing serum GDNF.

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APA: Copy

SABAGHI, AYOOB, HEYRANI, ALI, KIANI, AMIR, & YOUSOFVAND, NAMDAR. (2019). Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 7(1 ), 43-50. SID. https://sid.ir/paper/258035/en

Vancouver: Copy

SABAGHI AYOOB, HEYRANI ALI, KIANI AMIR, YOUSOFVAND NAMDAR. Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2019;7(1 ):43-50. Available from: https://sid.ir/paper/258035/en

IEEE: Copy

AYOOB SABAGHI, ALI HEYRANI, AMIR KIANI, and NAMDAR YOUSOFVAND, “Effect of Seizure During Pregnancy on Pentylenetetrazol-Induced Seizure-Like Behavior and Serum GDNF Levels in Adult Male Mice Offspring,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 7, no. 1 , pp. 43–50, 2019, [Online]. Available: https://sid.ir/paper/258035/en

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