EFFECTS OF IRON ON THE NEURONAL DEGENERATION OF THE L4 DORSAL ROOT GANGLION IN AN ANIMAL MODEL OF SCIATIC NERVE TRANSECTION

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOHAMMADI ABISOFLA SOMAYE; BEHNAM RASOULI MORTEZA; MOUSAVINEZHAD MOGHADDAM MARYAM; MAHDAVI SHAHRI NASER

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:4 Page(s): 24-33

Download Full-Text

Persian Verion

View:

627

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF IRON ON THE NEURONAL DEGENERATION OF THE L4 DORSAL ROOT GANGLION IN AN ANIMAL MODEL OF SCIATIC NERVE TRANSECTION

Author(s)

MOHAMMADI ABISOFLA SOMAYE | BEHNAM RASOULI MORTEZA | MOUSAVINEZHAD MOGHADDAM MARYAM | MAHDAVI SHAHRI NASER | Issue Writer Certificate

Keywords

IRONQ2

SCIATIC NERVEQ2

RATSQ2

Abstract

Introduction: IRON is an essential and potentially toxic metal in the mammalian body. In the present study, the effects of Ferrous Sulphate as an exogenous IRON on the neuronal degeneration induced by unilateral SCIATIC NERVE transection (SNT) in L4 dorsal root ganglion (L4-DRG) have been investigated in RATS.Materials and Methods: Twenty-four male Wistar rat were divided into 4 groups (n=6); control (intact), SNT+Salin, SNT+IRON (5.6 mg/kg; i.p), and sham. Treatment was started 1 hour after injury and continued for 7 days following the injury. The L4-DRG were dissected out, fixed (formalin 10%) and then processed for paraffin embedding 3 weeks after injury. Serial sections of L4-DRGs were prepared, stained (H& E and Toluidine blue) and examined microscopically. The mean volume of L4-DRG was estimated using Cavalieri principle and neuron count was done by a stereological approach (Disector method).Results: The mean number of neurons in SNT and SNT+IRON groups were significantly decreased compared to the control group. In addition, themean DRG volume in SNT+IRON group was significantly lower than control group.Conclusion: Treatment with IRON seems to exacerbate the neuronal death induced by SNT in RATS.

Cites

No record.

References

Iron availability compromises not only oligodendrocytes but also as trocytes and microglial cells

Cite

APA: Copy

MOHAMMADI ABISOFLA, SOMAYE, BEHNAM RASOULI, MORTEZA, MOUSAVINEZHAD MOGHADDAM, MARYAM, & MAHDAVI SHAHRI, NASER. (2018). EFFECTS OF IRON ON THE NEURONAL DEGENERATION OF THE L4 DORSAL ROOT GANGLION IN AN ANIMAL MODEL OF SCIATIC NERVE TRANSECTION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(4 ), 24-33. SID. https://sid.ir/paper/258043/en

Vancouver: Copy

MOHAMMADI ABISOFLA SOMAYE, BEHNAM RASOULI MORTEZA, MOUSAVINEZHAD MOGHADDAM MARYAM, MAHDAVI SHAHRI NASER. EFFECTS OF IRON ON THE NEURONAL DEGENERATION OF THE L4 DORSAL ROOT GANGLION IN AN ANIMAL MODEL OF SCIATIC NERVE TRANSECTION. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(4 ):24-33. Available from: https://sid.ir/paper/258043/en

IEEE: Copy

SOMAYE MOHAMMADI ABISOFLA, MORTEZA BEHNAM RASOULI, MARYAM MOUSAVINEZHAD MOGHADDAM, and NASER MAHDAVI SHAHRI, “EFFECTS OF IRON ON THE NEURONAL DEGENERATION OF THE L4 DORSAL ROOT GANGLION IN AN ANIMAL MODEL OF SCIATIC NERVE TRANSECTION,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 4 , pp. 24–33, 2018, [Online]. Available: https://sid.ir/paper/258043/en

Related Journal Papers