THE ROLE OF SEMAPHORINS AND THEIR RECEPTORS IN THE IMMUNE SYSTEM AND THEIR RELATION TO MULTIPLE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

LOTFI RAMIN; YARI KHEIROLLAH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2018 | Volume:6 | Issue:4 Page(s): 75-92

Download Full-Text

Persian Verion

View:

730

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF SEMAPHORINS AND THEIR RECEPTORS IN THE IMMUNE SYSTEM AND THEIR RELATION TO MULTIPLE

Author(s)

LOTFI RAMIN | YARI KHEIROLLAH | Issue Writer Certificate

Keywords

SEMAPHORINSQ2

IMMUNE SYSTEMQ1

INFLAMMATIONQ2

AUTOIMMUNE DISEASESQ2

MULTIPLE SCLEROSISQ2

Abstract

Introduction: SEMAPHORINS are large family of secretory and membrane-bound proteins that first were recognized in the nervous system as axon guidance molecules. SEMAPHORINS family has more than 30 members and has been classified into eight subclasses. Different classes of these molecules involved in various phases of immune responses are considered as immune SEMAPHORINS. Main receptors for SEMAPHORINS are plexins and neuropilins. Moreover, other types of molecules can act as receptor for SEMAPHORINS, such as TIM-2 (T cell, immunoglobulin, and mucin domain protein 2) and CD72 that bind to Sema 4A (Semaphorin 4A), and Sema 4D. Both forms of SEMAPHORINS, namely secretory and membrane-bound SEMAPHORINS, play important roles in the IMMUNE SYSTEM. MULTIPLE SCLEROSIS (MS), a chronic inflammatory autoimmune disease, is characterized by infiltration of lymphocytes into the central nervous system and demyelination. Recent investigations have shown that increased serum level or increased expression of some immune SEMAPHORINS is associated with severity of MS disease. Moreover, immune SEMAPHORINS-deficient mice are resistant to experimental autoimmune encephalomyelitis, which is attributed to impaired production of myelin basic protein-specific T cells.Conclusion: Identification of specific expression patterns of SEMAPHORINS and their receptors in the nervous system and a comprehensive understanding of their function in autoimmune brain disorders could provide a novel biomarker and therapeutic target for these disorders. The present study reviews the role of SEMAPHORINS and their receptors in the development and differentiation of immune cells and their relation to MS.

Cites

No record.

References

Cite

APA: Copy

LOTFI, RAMIN, & YARI, KHEIROLLAH. (2018). THE ROLE OF SEMAPHORINS AND THEIR RECEPTORS IN THE IMMUNE SYSTEM AND THEIR RELATION TO MULTIPLE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 6(4 ), 75-92. SID. https://sid.ir/paper/258045/en

Vancouver: Copy

LOTFI RAMIN, YARI KHEIROLLAH. THE ROLE OF SEMAPHORINS AND THEIR RECEPTORS IN THE IMMUNE SYSTEM AND THEIR RELATION TO MULTIPLE. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2018;6(4 ):75-92. Available from: https://sid.ir/paper/258045/en

IEEE: Copy

RAMIN LOTFI, and KHEIROLLAH YARI, “THE ROLE OF SEMAPHORINS AND THEIR RECEPTORS IN THE IMMUNE SYSTEM AND THEIR RELATION TO MULTIPLE,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 6, no. 4 , pp. 75–92, 2018, [Online]. Available: https://sid.ir/paper/258045/en

Related Journal Papers