PROTECTIVE EFFECTS OF DNA VACCINE ENCODING GLYCOPROTEIN D-1 OF HERPES SIMPLEX VIRUS TYPE 1 ON LATENCY RATE IN TRIGEMINAL GANGLIA

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GHAEMI AMIR; SOLEIMANJAHI HOORIEH

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Journal: Neuroscience Journal of Shefaye Khatam Year:2013 | Volume:1 | Issue:1 Page(s): 37-40

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Title

PROTECTIVE EFFECTS OF DNA VACCINE ENCODING GLYCOPROTEIN D-1 OF HERPES SIMPLEX VIRUS TYPE 1 ON LATENCY RATE IN TRIGEMINAL GANGLIA

Author(s)

GHAEMI AMIR | SOLEIMANJAHI HOORIEH | Issue Writer Certificate

Keywords

HERPES SIMPLEX VIRUS TYPE-1Q4

DNA VACCINEQ4

TRIGEMINAL GANGLIONQ4

Abstract

Introduction: Herpes simplex encephalitis (HSE) is a rare but very serious disorder caused by herpes simplex type 1 virus (HSV-1). Following primary HSV-1 infection, viral latency develops in the trigeminal ganglia (TG). Therefore, prevention from primary HSV -1 infection and subsequent latency establishment is an important feature for vaccine development.Materials & Methods: We evaluate efficacy of DNA VACCINE encoding Glycoprotein D-1 (gD-1) gene of HSV-1 against lethal ocularly challenge of TCID 5´105 plaque-forming units (pfu) per eye of wild HSV-1 versus negative control groups.Results: The data demonstrated protective effects of DNA VACCINE encoding Herpes simplex virus Glycoprotein D gene on latency rate in TG and mortality rate.Conclusion: These results indicated that immunization with g D-1 DNA VACCINE is a promising approach for eliciting a protective immunity against a HSV-1 lethal ocular challenge.

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APA: Copy

GHAEMI, AMIR, & SOLEIMANJAHI, HOORIEH. (2013). PROTECTIVE EFFECTS OF DNA VACCINE ENCODING GLYCOPROTEIN D-1 OF HERPES SIMPLEX VIRUS TYPE 1 ON LATENCY RATE IN TRIGEMINAL GANGLIA. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 1(1), 37-40. SID. https://sid.ir/paper/258062/en

Vancouver: Copy

GHAEMI AMIR, SOLEIMANJAHI HOORIEH. PROTECTIVE EFFECTS OF DNA VACCINE ENCODING GLYCOPROTEIN D-1 OF HERPES SIMPLEX VIRUS TYPE 1 ON LATENCY RATE IN TRIGEMINAL GANGLIA. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2013;1(1):37-40. Available from: https://sid.ir/paper/258062/en

IEEE: Copy

AMIR GHAEMI, and HOORIEH SOLEIMANJAHI, “PROTECTIVE EFFECTS OF DNA VACCINE ENCODING GLYCOPROTEIN D-1 OF HERPES SIMPLEX VIRUS TYPE 1 ON LATENCY RATE IN TRIGEMINAL GANGLIA,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 1, no. 1, pp. 37–40, 2013, [Online]. Available: https://sid.ir/paper/258062/en

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