THE EFFECT OF MANIPULATION OF NEURAL ACTIVITY OF DORSOLATERAL PREFRONTAL CORTEX ON COGNITIVE FLEXIBILITY DEFICIT

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REZANEJAD ASL AMIN; ISSAZADEGAN ALI; MIKAELI MANEI FARZANEH

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:2 Page(s): 1-10

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Title

THE EFFECT OF MANIPULATION OF NEURAL ACTIVITY OF DORSOLATERAL PREFRONTAL CORTEX ON COGNITIVE FLEXIBILITY DEFICIT

Author(s)

REZANEJAD ASL AMIN | ISSAZADEGAN ALI | MIKAELI MANEI FARZANEH | Issue Writer Certificate

Keywords

INTERNEURONSQ2

PLIABILITYQ2

PREFRONTAL CORTEXQ2

Abstract

Introduction: Deficit in cognitive flexibility has been observed in several mental and brain disorders. The dorsolateral PREFRONTAL CORTEX is the most important brain region involved in cognitive flexibility related tasks. Using a computer model of neuronal stimulation, the aim of this study was to investigate the effects of manipulating neural activity in this brain region on cognitive flexibility.Materials and Methods: A computer simulation approach was used. Simulation was in the context of Leabra cognitive architecture and by using PBWM model was implemented.Results: This study shows that increasing neural activity percent in the dorsal lateral PREFRONTAL CORTEX linearly decreased cognitive flexibility. In addition, reduction of neural activity in this region of the brain decreased cognitive flexibility in a larger extent.Conclusion: These data indicate that hypo- or hyperactivity of inhibitory INTERNEURONS in the dorsal lateral PREFRONTAL CORTEX can cause deficit in cognitive flexibility.Manipulation of neural activity in this region can distinguish two subgroups of patients with impaired cognitive ﬂexibility.

Cites

THE EFFECT OF MIDBRAIN PHASIC DOPAMINE SIGNAL MANIPULATION ON COGNITIVE CONTROL DEFICIT

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APA: Copy

REZANEJAD ASL, AMIN, ISSAZADEGAN, ALI, & MIKAELI MANEI, FARZANEH. (2016). THE EFFECT OF MANIPULATION OF NEURAL ACTIVITY OF DORSOLATERAL PREFRONTAL CORTEX ON COGNITIVE FLEXIBILITY DEFICIT. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(2), 1-10. SID. https://sid.ir/paper/258073/en

Vancouver: Copy

REZANEJAD ASL AMIN, ISSAZADEGAN ALI, MIKAELI MANEI FARZANEH. THE EFFECT OF MANIPULATION OF NEURAL ACTIVITY OF DORSOLATERAL PREFRONTAL CORTEX ON COGNITIVE FLEXIBILITY DEFICIT. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(2):1-10. Available from: https://sid.ir/paper/258073/en

IEEE: Copy

AMIN REZANEJAD ASL, ALI ISSAZADEGAN, and FARZANEH MIKAELI MANEI, “THE EFFECT OF MANIPULATION OF NEURAL ACTIVITY OF DORSOLATERAL PREFRONTAL CORTEX ON COGNITIVE FLEXIBILITY DEFICIT,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 2, pp. 1–10, 2016, [Online]. Available: https://sid.ir/paper/258073/en

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