CELL THERAPY STRATEGIES IN THE REPAIR OF SPINAL CORD INJURY: PROS AND CONS

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ABDOLAHI SARA; ALIGHOLI HADI; SHIRIAN SADEGH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Neuroscience Journal of Shefaye Khatam Year:2016 | Volume:4 | Issue:1 Page(s): 55-66

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Title

CELL THERAPY STRATEGIES IN THE REPAIR OF SPINAL CORD INJURY: PROS AND CONS

Author(s)

ABDOLAHI SARA | ALIGHOLI HADI | SHIRIAN SADEGH | Issue Writer Certificate

Keywords

STEM CELLSQ2

CENTRAL NERVOUS SYSTEMQ2

SPINAL CORD INJURIESQ2

CELL TRANSPLANTATIONQ3

Abstract

Introduction: The regeneration capacity of the CENTRAL NERVOUS SYSTEM (CNS) is very limited in the traumatic and non-traumatic injuries. Spinal cord injury (SCI) is the most common traumatic injuries in the CNS. Cell therapies have been tested to repair the neurodegenerative conditions of the CNS by different type of STEM CELLS. Cell Therapy approaches focused on targeting the pathophysiology of SCI, in particular to replace lost neuronal and/or glial cells, provide a more favorable growth environment and neutralize inhibitory molecules. Neural stem/progenitor cells, glial precursors, olfactory ensheathing glial cells, mesenchymal STEM CELLS, and Schwann cells are commonly used as the traditional cell transplants in experimental SCI studies, which may induce some advantages and/or disadvantages. It has been indicated that cellular transplantation had positive effects on animal models of some neuronal diseases.However, potential limitations and some concerns regarding the immunity of cell therapy are considered.Conclusion: The various STEM CELLS candidates for cell therapy may provide positive therapeutic effects in SCI. These cells have some advantages and disadvantages.Among these cells, well-differentiated induced pluripotent STEM CELLS and their derivatives in vitro can be used as an autologous source in SCI patients.

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APA: Copy

ABDOLAHI, SARA, ALIGHOLI, HADI, & SHIRIAN, SADEGH. (2016). CELL THERAPY STRATEGIES IN THE REPAIR OF SPINAL CORD INJURY: PROS AND CONS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 4(1), 55-66. SID. https://sid.ir/paper/258083/en

Vancouver: Copy

ABDOLAHI SARA, ALIGHOLI HADI, SHIRIAN SADEGH. CELL THERAPY STRATEGIES IN THE REPAIR OF SPINAL CORD INJURY: PROS AND CONS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2016;4(1):55-66. Available from: https://sid.ir/paper/258083/en

IEEE: Copy

SARA ABDOLAHI, HADI ALIGHOLI, and SADEGH SHIRIAN, “CELL THERAPY STRATEGIES IN THE REPAIR OF SPINAL CORD INJURY: PROS AND CONS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 4, no. 1, pp. 55–66, 2016, [Online]. Available: https://sid.ir/paper/258083/en

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