NEUROPROTECTIVE EFFECTS OF STIRIPENTOL ON OXYGEN-GLUCOSE DEPRIVATION IN PRIMARY CULTURE OF FETAL MICE CORTICAL NEURONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FOTOVAT ESKANDARI NOOROLHODA; VAHABZADEH GELAREH; GOLAB FERESHTEH; KARIMZADEH FARIBA; Rahimi Moghadam Parvaneh; NASIRIPOUR SOMAYYEH; SHABANI ROBABEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Neuroscience Journal of Shefaye Khatam Year:2017 | Volume:5 | Issue:1 Page(s): 10-17

Download Full-Text

Persian Verion

View:

622

Download:

Cites:

Information Journal Paper

Title

NEUROPROTECTIVE EFFECTS OF STIRIPENTOL ON OXYGEN-GLUCOSE DEPRIVATION IN PRIMARY CULTURE OF FETAL MICE CORTICAL NEURONS

Author(s)

Keywords

GAMMA-AMINOBUTYRIC ACIDQ2

ISCHEMIAQ2

MICEQ2

Abstract

Introduction: Excessive activation of NMDA receptors in ischemic injury as well as reduction of GABAergic system leads to discrepancies of ionic homeostasis and neuronal death. The aim of the present study was to evaluate the effect of different concentrations of stiripentol (0.01, 0.1, 1, 5, 10, 30 μM) as a GABAA receptor agonist on primary cortical culture of MICE on 4 h oxygen- glucose deprivation (OGD). Materials and Methods: After 24h of incubation of neuronal cells with stiripentol, the cells were transferred to glucose - free DMEM (Dulbecco ’ s ModifiedEagle Medium) and were exposed to 4h hypoxia in a small anaerobic chamber and incubated in standard condition for 24h. Cell viability was evaluated by MTT assay.Results: The results showed that different concentrations of stiripentol could increase the cell viability after 4h OGD Recovery(OGD / R). However, the protective effect of stiripentol was lower than the control group(the cells did not expose to OGD / R).Conclusion: Our results indicated that stiripentol could be a potential drug for treatment of brain ischemic condition. However, additional studies are needed to evaluate the mechanims of strripentol effect.

Cites

No record.

References

Cite

APA: Copy

FOTOVAT ESKANDARI, NOOROLHODA, VAHABZADEH, GELAREH, GOLAB, FERESHTEH, KARIMZADEH, FARIBA, Rahimi Moghadam, Parvaneh, NASIRIPOUR, SOMAYYEH, & SHABANI, ROBABEH. (2017). NEUROPROTECTIVE EFFECTS OF STIRIPENTOL ON OXYGEN-GLUCOSE DEPRIVATION IN PRIMARY CULTURE OF FETAL MICE CORTICAL NEURONS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 5(1), 10-17. SID. https://sid.ir/paper/258115/en

Vancouver: Copy

FOTOVAT ESKANDARI NOOROLHODA, VAHABZADEH GELAREH, GOLAB FERESHTEH, KARIMZADEH FARIBA, Rahimi Moghadam Parvaneh, NASIRIPOUR SOMAYYEH, SHABANI ROBABEH. NEUROPROTECTIVE EFFECTS OF STIRIPENTOL ON OXYGEN-GLUCOSE DEPRIVATION IN PRIMARY CULTURE OF FETAL MICE CORTICAL NEURONS. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2017;5(1):10-17. Available from: https://sid.ir/paper/258115/en

IEEE: Copy

NOOROLHODA FOTOVAT ESKANDARI, GELAREH VAHABZADEH, FERESHTEH GOLAB, FARIBA KARIMZADEH, Parvaneh Rahimi Moghadam, SOMAYYEH NASIRIPOUR, and ROBABEH SHABANI, “NEUROPROTECTIVE EFFECTS OF STIRIPENTOL ON OXYGEN-GLUCOSE DEPRIVATION IN PRIMARY CULTURE OF FETAL MICE CORTICAL NEURONS,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 5, no. 1, pp. 10–17, 2017, [Online]. Available: https://sid.ir/paper/258115/en

Related Journal Papers