The Role of Metals in Neurodegenerative Diseases of the Central Nervous System

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Montazeri Afshin; Akhlaghi Milad; BARAHIMI AHMADREZA; JAHANBAZI JAHAN ABAD ALI; JABBARI REZA

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Journal: Neuroscience Journal of Shefaye Khatam Year:2020 | Volume:8 | Issue:2 Page(s): 130-146

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Title

The Role of Metals in Neurodegenerative Diseases of the Central Nervous System

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Keywords

Heavy Metal PoisoningQ1

Nervous SystemQ2

Nerve DegenerationQ1

Abstract

Introduction: Metals have always proved their nature as integral parts of the Earth’ s crust, water, air and various ecosystems. Rare metals are commonly used as enzyme cofactors and act to regulate the cell functions. The accumulation of metals in the brain indicates the important role of these substances in the Nervous System. The lack of these metals is associated with a variety of neurological diseases. On the other hand, enhancement of metal levels may lead to various harmful intracellular events, including oxidative s tress, mitochondrial dysfunction, DNA fragmentation, protein falsity, endoplasmic endothelial s tress, disturbance in autophagy and induction of apoptosis. To date, adverse effects of metal imbalances with multiple human diseases, such as Alzheimer’ s disease, amyotrophic lateral sclerosis, autism spectrum disorders, Guillen-Barre disease, Persian Gulf War syndrome, Huntington’ s disease, multiple sclerosis, Parkinson’ s disease, and Wilson’ s disease, have been reported. The role of some of these metal ions, especially in brain function, is important, which led to the introduction of the term metalloneurochemis try to describe the study of metallic ions in the Nervous System at the molecular level. Conclusion: Various metals play an important role in the regulation of multiple vital processes of neurons. Deficiency or elevated levels of any of these metals have harmful effects on the human Nervous System, which may contribute to different neurodegenerative diseases.

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APA: Copy

Montazeri, Afshin, Akhlaghi, Milad, BARAHIMI, AHMADREZA, JAHANBAZI JAHAN ABAD, ALI, & JABBARI, REZA. (2020). The Role of Metals in Neurodegenerative Diseases of the Central Nervous System. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 8(2 ), 130-146. SID. https://sid.ir/paper/258167/en

Vancouver: Copy

Montazeri Afshin, Akhlaghi Milad, BARAHIMI AHMADREZA, JAHANBAZI JAHAN ABAD ALI, JABBARI REZA. The Role of Metals in Neurodegenerative Diseases of the Central Nervous System. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2020;8(2 ):130-146. Available from: https://sid.ir/paper/258167/en

IEEE: Copy

Afshin Montazeri, Milad Akhlaghi, AHMADREZA BARAHIMI, ALI JAHANBAZI JAHAN ABAD, and REZA JABBARI, “The Role of Metals in Neurodegenerative Diseases of the Central Nervous System,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 8, no. 2 , pp. 130–146, 2020, [Online]. Available: https://sid.ir/paper/258167/en

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