INVESTIGATION ON THE MOTOR RECOVERY EFFECT OF A SELF-ASSEMBLING NANOFIBER IN THE SPINAL CORD INJURY MODEL IN RAT

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TAVAKOL SHIMA; ALIGHOLI HADI; ESHAGHABADI AREZOU; MODARRES MOUSAVI SAYED MOSTAFA; AI JAFAR; REZAYAT SEYED MEHDI

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Journal: Neuroscience Journal of Shefaye Khatam Year:2014 | Volume:2 | Issue:2 Page(s): 41-46

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Title

INVESTIGATION ON THE MOTOR RECOVERY EFFECT OF A SELF-ASSEMBLING NANOFIBER IN THE SPINAL CORD INJURY MODEL IN RAT

Author(s)

Keywords

SPINAL CORD INJURIESQ3

HYDROGELSQ2

LAMININQ3

TISSUE SCAFFOLDSQ3

Abstract

Introduction: Spinal cord injury (SCI) is a serious disabling condition associated with paralysis. Owing to suitable effects of HYDROGELS compared to preformed scaffolds, in this study a hydrogel based biomaterial, Matrigel, was applied. Matrigel is a termogel that forms nanofibers and hydrogel above 20°C. It contains LAMININ, nidogen and some growth factors that induce neural differentiation.Materials and Methods: A moderate spinal cord contusion was performed in adult rats and 10 days after injury, matrigel was implanted. Then, they follow up via Basso, Beattie, Bresnahan test for 42 days. Cresyl violet staining was performed as a histopatological analysis.Results: Our data indicated less inflammation and dark cells in Matrigel group compared to control group. Locomotor test showed significant improvement of motor recovery in Matrigel group.Conclusion: Our results suggest that Matrigel via some growth factors and adhesive molecules may have beneficial effects on functional recovery in SCI.

Cites

EFFECTS OF A SELF-ASSEMBLING PEPTIDE NANOFIBER CONTAINING LAMININ MOTIF ON SURVIVAL AND PROLIFERATION OF EMBRYONIC RAT NEURAL STEM CELLS

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APA: Copy

TAVAKOL, SHIMA, ALIGHOLI, HADI, ESHAGHABADI, AREZOU, MODARRES MOUSAVI, SAYED MOSTAFA, AI, JAFAR, & REZAYAT, SEYED MEHDI. (2014). INVESTIGATION ON THE MOTOR RECOVERY EFFECT OF A SELF-ASSEMBLING NANOFIBER IN THE SPINAL CORD INJURY MODEL IN RAT. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, 2(2), 41-46. SID. https://sid.ir/paper/258214/en

Vancouver: Copy

TAVAKOL SHIMA, ALIGHOLI HADI, ESHAGHABADI AREZOU, MODARRES MOUSAVI SAYED MOSTAFA, AI JAFAR, REZAYAT SEYED MEHDI. INVESTIGATION ON THE MOTOR RECOVERY EFFECT OF A SELF-ASSEMBLING NANOFIBER IN THE SPINAL CORD INJURY MODEL IN RAT. NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM[Internet]. 2014;2(2):41-46. Available from: https://sid.ir/paper/258214/en

IEEE: Copy

SHIMA TAVAKOL, HADI ALIGHOLI, AREZOU ESHAGHABADI, SAYED MOSTAFA MODARRES MOUSAVI, JAFAR AI, and SEYED MEHDI REZAYAT, “INVESTIGATION ON THE MOTOR RECOVERY EFFECT OF A SELF-ASSEMBLING NANOFIBER IN THE SPINAL CORD INJURY MODEL IN RAT,” NEUROSCIENCE JOURNAL OF SHEFAYE KHATAM, vol. 2, no. 2, pp. 41–46, 2014, [Online]. Available: https://sid.ir/paper/258214/en

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