Investigation of the Interaction of Antitumor Palladium and Platinum Complexes of Ethyldithiocarbamate with Human Serum Albumin

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ESLAMI MOGHADAM MAHBOUBE; MANSOURI TORSHIZI HASSAN; SAEIDIFAR MARYAM

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Journal: Nashrieh Shimi va Mohandesi Shimi Iran Year:2019 | Volume:37 | Issue:4 (90) Page(s): 155-166

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Title

Investigation of the Interaction of Antitumor Palladium and Platinum Complexes of Ethyldithiocarbamate with Human Serum Albumin

Author(s)

ESLAMI MOGHADAM MAHBOUBE | MANSOURI TORSHIZI HASSAN | SAEIDIFAR MARYAM | Issue Writer Certificate

Keywords

Pt(II) and Pd(II) complexesQ1

HSA interactionQ1

EthyldithiocarbamateQ1

Human albumin serumQ1

Binding parametersQ1

Thermodynamic parametersQ1

Abstract

In this work, two Platinum (II) and Palladium (II) complexes of 2, 2'-bipyridine (bpy) and diEthyldithiocarbamate (Et-dtc) with anti-tumor activity against K562 were selected. The Cc50 values of Pd and Pt compounds are 55 and 89 micromolar, respectively that are lower than cisplatin. These complexes interacted with human serum albumin (HSA) in Tris-buffer containing 10 mM NaCl, pH=7. 4 at 27 and 37 ° C by spectroscopic methods. Results obtained from denaturation studies indicate that probably Pd(II) complex denature the HSA while the Pt(II) does not so. Isothermal titration data indicated that the stability of protein decrease by increasing complex concentration and the denaturation process is exothermic. Binding of these cationic complexes with HSA occurs by electrostatic interaction. These complexes can denature HSA at very low concentrations of the micromolar spatially platinum complex. Fluorescence studies showed the intensity of HSA quenched in the presence of each Pt or Pd complex and quenching mechanism seems to be static. Circular dichroism spectra of HSA were recorded and the percentage of alpha helicity in the presence of Pd and Pt complexes were investigated 5 and 3%, respectively.

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APA: Copy

ESLAMI MOGHADAM, MAHBOUBE, MANSOURI TORSHIZI, HASSAN, & SAEIDIFAR, MARYAM. (2019). Investigation of the Interaction of Antitumor Palladium and Platinum Complexes of Ethyldithiocarbamate with Human Serum Albumin. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), 37(4 (90) ), 155-166. SID. https://sid.ir/paper/26035/en

Vancouver: Copy

ESLAMI MOGHADAM MAHBOUBE, MANSOURI TORSHIZI HASSAN, SAEIDIFAR MARYAM. Investigation of the Interaction of Antitumor Palladium and Platinum Complexes of Ethyldithiocarbamate with Human Serum Albumin. NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN)[Internet]. 2019;37(4 (90) ):155-166. Available from: https://sid.ir/paper/26035/en

IEEE: Copy

MAHBOUBE ESLAMI MOGHADAM, HASSAN MANSOURI TORSHIZI, and MARYAM SAEIDIFAR, “Investigation of the Interaction of Antitumor Palladium and Platinum Complexes of Ethyldithiocarbamate with Human Serum Albumin,” NASHRIEH SHIMI VA MOHANDESI SHIMI IRAN (PERSIAN), vol. 37, no. 4 (90) , pp. 155–166, 2019, [Online]. Available: https://sid.ir/paper/26035/en

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