HISTOLOGICAL STUDY OF THERAPEUTIC ANGIOGENESIS IN RAT BY TISSUE ENGINEERING METHOD: ROLE OF BONE MARROW MAST CELLS AND PLATELETS IN INDUCTION OF ANGIOGENESIS

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KARIMI ALI; SHAHROOZ RASOUL; HOBBENAGHI RAHIM; MOHAMMADI RAHIM; MORTAZ ESMAEIL; SOLTANALINEJAD FARHAD; NAJAFI GHOLAMREZA; Amani Saeede

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Journal: Journal of Neyshabur University of Medical Sciences Year:2017 | Volume:4 | Issue:4 Page(s): 22-32

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Title

HISTOLOGICAL STUDY OF THERAPEUTIC ANGIOGENESIS IN RAT BY TISSUE ENGINEERING METHOD: ROLE OF BONE MARROW MAST CELLS AND PLATELETS IN INDUCTION OF ANGIOGENESIS

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Keywords

ANGIOGENESISQ2

MAST CELLSQ2

TISSUE ENGINEERINGQ2

PLATELETSQ3

HISTOLOGYQ2

Abstract

Introduction: Peripheral arterial disease is the result of obstruction of blood circulation. MAST CELLS and PLATELETS via induction of ANGIOGENESIS may cause the enhancement of amelioration local ischemia. The aim of this study was help to find an appropriate approach to recovery of ischemic condition in the restricted femoral artery localization.Materials and Methods 30 male white Wistar rats were divided into 6 ischemic experimental groups (n=5), randomly: Ischemia control group: the femoral artery was transected‚ Phosphate buffer control solution (PBS) group: the transected location was immersed with PBS, Chitosan control group (CHIT): the transected location was immersed with chitosan solution, Mast cell transplanted experimental group (CHIT/Mast cells): the transected location was immersed with chitosan and MAST CELLS (1× 106). PLATELETS transplanted experimental group (CHIT/plat): the transected location was immersed with chitosan and PLATELETS (13×106). PLATELETS and MAST CELLS transplanted experimental group (CHIT/plat/Mast cells): the transected location was immersed with chitosan, 13×106 PLATELETS and MAST CELLS (1×106).Results Analyses of capillary density and histomorphometrical analysis were performed on day 7 after surgery. Mean number of blood vessels in CHIT/Mast cells group indicated a significant difference compared to other experimental groups (P<0.05). The mean number of medium and large blood vessels in CHIT/Mast cells group was significantly more than control groups (P<0.05).Conclusion MAST CELLS using in TISSUE ENGINEERING could offer a new approach for therapeutic ANGIOGENESIS which is able to provide improved neovascularization in cases of peripheral arterial diseases.

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APA: Copy

KARIMI, ALI, SHAHROOZ, RASOUL, HOBBENAGHI, RAHIM, MOHAMMADI, RAHIM, MORTAZ, ESMAEIL, SOLTANALINEJAD, FARHAD, NAJAFI, GHOLAMREZA, & Amani, Saeede. (2017). HISTOLOGICAL STUDY OF THERAPEUTIC ANGIOGENESIS IN RAT BY TISSUE ENGINEERING METHOD: ROLE OF BONE MARROW MAST CELLS AND PLATELETS IN INDUCTION OF ANGIOGENESIS. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, 4(4 ), 22-32. SID. https://sid.ir/paper/264415/en

Vancouver: Copy

KARIMI ALI, SHAHROOZ RASOUL, HOBBENAGHI RAHIM, MOHAMMADI RAHIM, MORTAZ ESMAEIL, SOLTANALINEJAD FARHAD, NAJAFI GHOLAMREZA, Amani Saeede. HISTOLOGICAL STUDY OF THERAPEUTIC ANGIOGENESIS IN RAT BY TISSUE ENGINEERING METHOD: ROLE OF BONE MARROW MAST CELLS AND PLATELETS IN INDUCTION OF ANGIOGENESIS. JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;4(4 ):22-32. Available from: https://sid.ir/paper/264415/en

IEEE: Copy

ALI KARIMI, RASOUL SHAHROOZ, RAHIM HOBBENAGHI, RAHIM MOHAMMADI, ESMAEIL MORTAZ, FARHAD SOLTANALINEJAD, GHOLAMREZA NAJAFI, and Saeede Amani, “HISTOLOGICAL STUDY OF THERAPEUTIC ANGIOGENESIS IN RAT BY TISSUE ENGINEERING METHOD: ROLE OF BONE MARROW MAST CELLS AND PLATELETS IN INDUCTION OF ANGIOGENESIS,” JOURNAL OF NEYSHABUR UNIVERSITY OF MEDICAL SCIENCES, vol. 4, no. 4 , pp. 22–32, 2017, [Online]. Available: https://sid.ir/paper/264415/en

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