THE INFLUNCE OF CARRY-OVER EFFECT ON SAMPLE SIZE AND POWER OF THE.TEST
IN 2X2 CROSS-OVER STUDY

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SOLEYMANI B.; FAGHIHZADEH S.; KAZEMNEJAD ANOUSHIRAVAN; BABAEI G.H.

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Paper Information

Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:8 | Issue:2 Page(s): 11-16

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Information Journal Paper

Title

THE INFLUNCE OF CARRY-OVER EFFECT ON SAMPLE SIZE AND POWER OF THE.TEST IN 2X2 CROSS-OVER STUDY

Author(s)

SOLEYMANI B. | FAGHIHZADEH S. | KAZEMNEJAD ANOUSHIRAVAN | BABAEI G.H. | Issue Writer Certificate

Keywords

2X2 CROSS-OVER STUDYQ4

SAMPLE SIZEQ3

CARRY-OVER EFFECTQ4

Abstract

The problem of CARRY-OVER EFFECT in two period -two sequence cross-over studies has already brought about a lot of discussion and has induced to bring up different views and recommendations. The present study deals with relationship between CARRY-OVER EFFECTs and SAMPLE SIZE in 2x2 cross-over design. It has been shown that when such effects exist, number of samples will differ from the case when there is no CARRY-OVER EFFECT. The difference in sampel size has been estimated and has been shown that depends upon the differences in size and direction of CARRY-OVER EFFECT and direct treatment effects. The influence of CARRY-OVER EFFECTs on power of the test also has been considered and its variation has been shown. The results suggest that while determining sampel size for a 2X2 CROSS-OVER STUDY, it is matter of wise to take into account any knowledge about CARRY-OVER EFFECT difference which is in hand from a previous or pilot study or even from a rational guess, especially if CARRY-OVER EFFECTs difference and direct treatment effects difference are in the same direction. Theoretical outcomes are used for a practical example and related results have been presented.

Cites

SAMPLE SIZE DETERMINATION FOR MATCHED STUDIES

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APA: Copy

SOLEYMANI, B., FAGHIHZADEH, S., KAZEMNEJAD, ANOUSHIRAVAN, & BABAEI, G.H.. (2003). THE INFLUNCE OF CARRY-OVER EFFECT ON SAMPLE SIZE AND POWER OF THE.TEST IN 2X2 CROSS-OVER STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 8(2), 11-16. SID. https://sid.ir/paper/26506/en

Vancouver: Copy

SOLEYMANI B., FAGHIHZADEH S., KAZEMNEJAD ANOUSHIRAVAN, BABAEI G.H.. THE INFLUNCE OF CARRY-OVER EFFECT ON SAMPLE SIZE AND POWER OF THE.TEST IN 2X2 CROSS-OVER STUDY. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;8(2):11-16. Available from: https://sid.ir/paper/26506/en

IEEE: Copy

B. SOLEYMANI, S. FAGHIHZADEH, ANOUSHIRAVAN KAZEMNEJAD, and G.H. BABAEI, “THE INFLUNCE OF CARRY-OVER EFFECT ON SAMPLE SIZE AND POWER OF THE.TEST IN 2X2 CROSS-OVER STUDY,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 8, no. 2, pp. 11–16, 2003, [Online]. Available: https://sid.ir/paper/26506/en

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