A COMPARISON OF COX AND FRAILTY MODELS IN PRESENCE OF UNKNOWN RISK FACTORS

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KHEYRI S.; FAGHIHZADEH S.; MESHKANI M.R.; MAHMOUDI M.; BABAEI G.H.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:8 | Issue:2 Page(s): 23-28

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Title

A COMPARISON OF COX AND FRAILTY MODELS IN PRESENCE OF UNKNOWN RISK FACTORS

Author(s)

Keywords

SURVIVAL ANALYSISQ3

UNKNOWN RISK FACTORSQ4

MULTIVARIATE SURVIVAL DATAQ4

COX PROPORTIONAL HAZARD MODELQ4

FRAILTY MODELQ3

Abstract

One of the most popular models for SURVIVAL ANALYSIS is the COX PROPORTIONAL HAZARD MODEL. In this model, the hazard function may depend on unknowon risk factors which are impossible to include them in the model. This will lead to an increase in the variability of responses, which implies biased and misleading estimates of the- parameters of the Cox model. This problem can be overcome by inclusion of a random effect in the Cox model. The modified model is known as FRAILTY MODEL.In this paper, we compare parameter estimates of Cox and FRAILTY MODELs with a simulation study. The results show that in the univariate survival data, as the number of UNKNOWN RISK FACTORS incrase so do the magnitude of the bias and the mean square error (MSE) of estimators in the Cox model compared to the FRAILTY MODEL. In bivariate survival data, magnitude of the biased and the mean square error of estimator of the Cox model depends on the magnitude of the correlation of survival times. In comparison, the FRAILTY MODELs remove the disadvantage of the Cox model by considering the correlation of the survival times.

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APA: Copy

KHEYRI, S., FAGHIHZADEH, S., MESHKANI, M.R., MAHMOUDI, M., & BABAEI, G.H.. (2003). A COMPARISON OF COX AND FRAILTY MODELS IN PRESENCE OF UNKNOWN RISK FACTORS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 8(2), 23-28. SID. https://sid.ir/paper/26507/en

Vancouver: Copy

KHEYRI S., FAGHIHZADEH S., MESHKANI M.R., MAHMOUDI M., BABAEI G.H.. A COMPARISON OF COX AND FRAILTY MODELS IN PRESENCE OF UNKNOWN RISK FACTORS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;8(2):23-28. Available from: https://sid.ir/paper/26507/en

IEEE: Copy

S. KHEYRI, S. FAGHIHZADEH, M.R. MESHKANI, M. MAHMOUDI, and G.H. BABAEI, “A COMPARISON OF COX AND FRAILTY MODELS IN PRESENCE OF UNKNOWN RISK FACTORS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 8, no. 2, pp. 23–28, 2003, [Online]. Available: https://sid.ir/paper/26507/en

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