THE EFFECTS OF SALVIA HYDRANGEA ON CELL-MEDIATED IMMUNE RESPONSE IN MICE

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JAFARIAN DEHKORDI ABAS; GHANNADI A.; KERAMATI N.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 115-120

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Title

THE EFFECTS OF SALVIA HYDRANGEA ON CELL-MEDIATED IMMUNE RESPONSE IN MICE

Author(s)

JAFARIAN DEHKORDI ABAS | GHANNADI A. | KERAMATI N. | Issue Writer Certificate

Keywords

SALVIA HYDRANGEAQ4

CELLULAR IMMUNITYQ3

POLYPHENOLIC EXTRACTQ4

Abstract

Introduction. S. hydrangea DC. ex Benth has been used as antireumatoid, analgesic, antihepatotoxic, carminative and antispasm in iranian traditional medicine. Also, its'anti-inflommatory, antihepatotoxic and antioxidant effects has been reported. In this study we sought to see whether S. hydrangra has any effect on immune system. Methods. S. hydrangea was collected from Dehaghan, identified and dried. Hydroalcoholic and POLYPHENOLIC EXTRACTs (by maceration) were prepared. Rosemarinic acid, a potent anti-inflommatory agent, was identified by thin layer chromatography and quantitated by spectrophotometer at 505 nm. To study the effects of S. hydrangea on acquired immunity, groups of Balb/c mice (n = 8) were used. SRBC was injected (sc, 1x108 cells/ml, 0.02 ml) and 5 days later hydroalocohofic extract (10-2000 mg/kg) and POLYPHENOLIC EXTRACT (4- 1000 mg/kg), betamethasone (4 mg/kg) or normal saline were given up. After one hour SRBC was injected to paw (sc, 1x108cells/ml, 0.02ml) and paw swelling was measured at specified intervals up to 72 hours. To investigate the effects of S. hydrangea on intrinsic immunity the same procedure was used but, animals only received one injection of SRBC to paw after administration of tested compounds. Results. The percent of concentrated total and POLYPHENOLIC EXTRACTs of S. hydrangea based on dried plant was 48.0 and 27.5 (W/W), respectively. The amount of hydroxy cynamic acid derivatives was 3.8%. Administration of SRBC induced paw swelling with maximum response at 6-8 hour in both models. Betamethasone (4 mg/kg) inhibited paw swelling in both models. Hydroalcoholic extract of S. hydrangea increased paw swelling in intrinsic immuiuty model, but its POLYPHENOLIC EXTRACT had no significant effect. Hydroalcoholic extract and Polyphenofic extract did not exhibit any effect on acquired immunity. Discussion. Our findings indicated different effects of hydroalcoholic and POLYPHENOLIC EXTRACTs of S. hydrangea on intrinsic and aquired immunity. To find out the cause of these differences, it is recomended to study the effects of different fraction of hydroxy cynamic acid and rosmarinic acid on cellular and humoral immunity.

Cites

THE EFFECTS OF MILK THISTLE - EXTRACT (SILYBUM MARIAMUM) AS MEDICAL HERBAL ON NON-SPECIFIC IMMUNE SYSTEM OF RAINBOW TROUT (ONCORHYNCHUS MYKISS)

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APA: Copy

JAFARIAN DEHKORDI, ABAS, GHANNADI, A., & KERAMATI, N.. (2003). THE EFFECTS OF SALVIA HYDRANGEA ON CELL-MEDIATED IMMUNE RESPONSE IN MICE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 115-120. SID. https://sid.ir/paper/26677/en

Vancouver: Copy

JAFARIAN DEHKORDI ABAS, GHANNADI A., KERAMATI N.. THE EFFECTS OF SALVIA HYDRANGEA ON CELL-MEDIATED IMMUNE RESPONSE IN MICE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):115-120. Available from: https://sid.ir/paper/26677/en

IEEE: Copy

ABAS JAFARIAN DEHKORDI, A. GHANNADI, and N. KERAMATI, “THE EFFECTS OF SALVIA HYDRANGEA ON CELL-MEDIATED IMMUNE RESPONSE IN MICE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 115–120, 2003, [Online]. Available: https://sid.ir/paper/26677/en

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