IN VITRO ANTIFUNGAL ACTIVITY OF 1-ALKYLIMIDAZOLES

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KABNADIDEH S.; SHADZI SH.; ALI POUR E.; MIRMOHAMMAD SADEGHI M.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 126-130

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Information Journal Paper

Title

IN VITRO ANTIFUNGAL ACTIVITY OF 1-ALKYLIMIDAZOLES

Author(s)

KABNADIDEH S. | SHADZI SH. | ALI POUR E. | MIRMOHAMMAD SADEGHI M. | Issue Writer Certificate

Keywords

ALKYLIMIDAZOLEQ4

ANTIFUNGALQ3

DERMATOPHYTEQ4

YEASTQ3

Abstract

Introduction. The prevalence of serious mycotic infections in humans and animals has dramatically increased in the past decades. Because of the emerging resistance to polyene antibiotics and Amphotericin B, imidazole and triazole derivatives have been recently developed. In this study the ANTIFUNGAL properties of 1-ALKYLIMIDAZOLEs have been determined.Methods. Three DERMATOPHYTEs (E.fluccosum, T.mentagrophytes, M.gypseum), two YEASTs (T.beigelli, C.albicans), one bacteria (N.asteroids) and three agar media (S, SC, SCC) were selected for this study. Six ALKYLIMIDAZOLEs with 8-14 carbons in their alkyl chains (octylimidazole, nonylimidazole, decylimidazole, undecylimidazole, dodecylimidazole, tetradecylimidazole) were used for demonstrating the ANTIFUNGAL effects of this type of compounds. The above derivatives were used in concentrations of 0.05%, 0.1% and 0.15% (V/V).Results. The results demonstrated, minimum inhibitory concentrations (MIC) 0.05% for dodecylimidazole, 0.1% for decyl and undecylimidazole, 0.1%-0.15% for nonyl and tetradecyfimidazofe and 0.15% for octylimidazole.Discussion. Out of the above ALKYLIMIDAZOLE derivatives, dodecylimidazole had the lowest MIC while octylimidazole had the highest MlC. Therefore it can be concluded that in the ALKYLIMIDAZOLE series the ANTIFUNGAL activity increases with the increase in the number of carbons in the alkyl chain (up to 12 carbons).

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APA: Copy

KABNADIDEH, S., SHADZI, SH., ALI POUR, E., & MIRMOHAMMAD SADEGHI, M.. (2003). IN VITRO ANTIFUNGAL ACTIVITY OF 1-ALKYLIMIDAZOLES. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 126-130. SID. https://sid.ir/paper/26687/en

Vancouver: Copy

KABNADIDEH S., SHADZI SH., ALI POUR E., MIRMOHAMMAD SADEGHI M.. IN VITRO ANTIFUNGAL ACTIVITY OF 1-ALKYLIMIDAZOLES. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):126-130. Available from: https://sid.ir/paper/26687/en

IEEE: Copy

S. KABNADIDEH, SH. SHADZI, E. ALI POUR, and M. MIRMOHAMMAD SADEGHI, “IN VITRO ANTIFUNGAL ACTIVITY OF 1-ALKYLIMIDAZOLES,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 126–130, 2003, [Online]. Available: https://sid.ir/paper/26687/en

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