TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLE

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ASILIAN A.; TAVAKOLIKIA R.; IRAJI F.; GHASEMI M.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2001 | Volume:6 | Issue:1 Page(s): 14-17

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Title

TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLE

Author(s)

ASILIAN A. | TAVAKOLIKIA R. | IRAJI F. | GHASEMI M. | Issue Writer Certificate

Keywords

ESTROGEN -TOPICALQ4

WOUND HEALINGQ4

CLINICAL TRIALQ4

YOUNG HEALTHY PEOPLEQ4

Abstract

Introduction: Acceleration of WOUND HEALING is intrested because of decreasing the risk of wound complication and infections as well as reducing the cost of treatment. In animal models, it has been proved that estrogen can accelerate WOUND HEALING. It has been also suggested that topical estrogen can eliminate effect of aging on WOUND HEALING and can increase the speed of WOUND HEALING in old people.Methods: We selected 16 YOUNG HEALTHY PEOPLE who developed symmetrical and ulcers (regarding size and depths) after dermabrasion, shave and electrocoagulouzon and CO2 laser. Primary lesions of patients were benign and noninfective. Identical and symmetrical lesions of each patient were randomly divided into two groups (A and B). Topical estrogen with concentration of 0.625 mg/g in the base of silver sulfadiazine cream was applied to A ulcers and silver sulfadiazine cream alone was applied on B ulcers. Ulcers were dressed by Telfa gauzes. The A ulcers of each patients were compared to counterpart B ulcers in regard of redness, size, depth, general appearance of ulcers and WOUND HEALING duration at three days intervals by a physician. Results: Average time of healing was 10.8 days and 8.5 days for B (n=29) and A (n=29) ulcers, respectively (P<0.001). In 78 percent of cases, the A ulcers were judged better than B ulcers by physician (P<0.01). Discussion: It seems that estrogen not only accelerates healing of acute ulcers but also it is efficient in YOUNG HEALTHY PEOPLE who don’t have any hormonal or WOUND HEALING problems.

Cites

THE EFFICACY OF MOHS MICROGRAPHIC SURGERY IN TREATMENT OF BASAL CELL CARCINOMA IN ISFAHAN AL-ZAHRA HOSPITAL FROM SEPTEMBER 1999 TO MARCH 2003

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APA: Copy

ASILIAN, A., TAVAKOLIKIA, R., IRAJI, F., & GHASEMI, M.. (2001). TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 6(1), 14-17. SID. https://sid.ir/paper/26786/en

Vancouver: Copy

ASILIAN A., TAVAKOLIKIA R., IRAJI F., GHASEMI M.. TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2001;6(1):14-17. Available from: https://sid.ir/paper/26786/en

IEEE: Copy

A. ASILIAN, R. TAVAKOLIKIA, F. IRAJI, and M. GHASEMI, “TOPICAL ESTROGEN IN WOUND HEALING: A DOUBLE BLIND RANDOMIZED CLINICAL TRIAL ON YOUNG HEALTHY PEOPLE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 6, no. 1, pp. 14–17, 2001, [Online]. Available: https://sid.ir/paper/26786/en

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