CAN THYMIC TISSUE INDUCE TOLERANCE TO KIDNEY ALLOGRAFTS?

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SHAKERI S.; AMIN SHARIFI A.R.; KHEZRI A.A.; MONABATI A.; TANIDEH N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: UROLOGY JOURNAL Year:2005 | Volume:2 | Issue:3 Page(s): 148-152

Download Full-Text

View:

276

Download:

134

Cites:

Information Journal Paper

Title

CAN THYMIC TISSUE INDUCE TOLERANCE TO KIDNEY ALLOGRAFTS?

Author(s)

Keywords

KIDNEY TRANSPLANTATION

THYMUS

THYMOKIDNEY

ALLOGRAFT REJECTION

CANINE

Abstract

Introduction: The aim of this study was to investigate the beneficial effect of donor thymic tissue to induce tolerance in THYMOKIDNEY allografts, transplanted to thymectomized cross-bred CANINEs. Materials and Methods: Seven pairs of transplant donors and recipients were selected from 3- to 4-month-old cross-bred CANINEs with major histocompatibility complex (MHC) mismatches. Recipients underwent partial thymectomy 4 weeks before transplantation and received an autologous thymic graft under the renal capsule, which had been engrafted in the donors 3 months before transplantation (thymokidney). Successful engraftment with evidence of thymocyte development in the donors was determined by gross and histologic examination at the time of transplantation. Biopsy specimens were obtained at the transplant day and 3 months after transplantation and were studied histologically for evidence of hyperacute or acute rejection.Results: At 90 days after the operation, all 7 juvenile thymic grafts had developed with normal thymic structure under the renal capsule. Hyperacute rejection was not observed in allografts, and all of them were functioning until the end of follow-up; however, all of the allografts showed acute cell-mediated rejection 3 months after transplantation. Conclusion: No tolerance was induced by vascularized donor THYMOKIDNEYs in MHC-mismatched CANINEs. The advantages of tolerance over chronic immunosuppression are so great that a potentially tolerogenic approach such as thymic transplantation would seem worthy of further investigations on large animal models. To evaluate the beneficial effects of thymic tissue in tolerance induction, utilizing a short course, low-dose adjuvant immunosuppressant to this regimen and/or application of in-bred MHC-matched CANINEs is suggested.

Cites

No record.

References

No record.

Cite

APA: Copy

SHAKERI, S., AMIN SHARIFI, A.R., KHEZRI, A.A., MONABATI, A., & TANIDEH, N.. (2005). CAN THYMIC TISSUE INDUCE TOLERANCE TO KIDNEY ALLOGRAFTS? . UROLOGY JOURNAL, 2(3), 148-152. SID. https://sid.ir/paper/270680/en

Vancouver: Copy

SHAKERI S., AMIN SHARIFI A.R., KHEZRI A.A., MONABATI A., TANIDEH N.. CAN THYMIC TISSUE INDUCE TOLERANCE TO KIDNEY ALLOGRAFTS? . UROLOGY JOURNAL[Internet]. 2005;2(3):148-152. Available from: https://sid.ir/paper/270680/en

IEEE: Copy

S. SHAKERI, A.R. AMIN SHARIFI, A.A. KHEZRI, A. MONABATI, and N. TANIDEH, “CAN THYMIC TISSUE INDUCE TOLERANCE TO KIDNEY ALLOGRAFTS? ,” UROLOGY JOURNAL, vol. 2, no. 3, pp. 148–152, 2005, [Online]. Available: https://sid.ir/paper/270680/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops