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Title

Y CHROMOSOME MICRODELETIONS IN IDIOPATHIC INFERTILE MEN FROM WEST AZARBAIJAN

Pages

  38-43

Abstract

 Introduction: Although assisted reproduction techniques are used extensively in Iran, screening for Y CHROMOSOME MICRODELETIONs before intracytoplasmic sperm injection is often undervalued. Our aim was to investigate Y CHROMOSOME MICRODELETIONs in men with idiopathic azoospermia or severe OLIGOSPERMIA. Materials and Methods: In 99 selected patients with azoospermia or severe OLIGOSPERMIA and elevated levels of follicle-stimulating hormone and luteinizing hormone in combination with low serum testosterone levels, 20 pairs of sequence-tagged site-based primer sets specific for the Y MICRODELETION loci were analyzed. Primers were chosen to cover azoospermia factor (AZF) regions as well as deleted in azoospermia (DAZ) and the sex-determining region on Y CHROMOSOME (SRY) genes. Also, 100 healthy men served as a control group. Results: Twenty-four patients (24.2%) had MICRODELETIONs in AZF genes, but no MICRODELETIONs were found in men in the control group. In 15 patients (62.5%), 1 deletion was found. Six patients (25%) had 2, and 3 (12.5%) had 3 deletions. The deletions mainly comprised the AZFc region (in 21 of 24 patients; 87.5%), which corresponds to the DAZ gene. Deletions in AZFb were found in 7 patients (29.2%), and 4 (16.7%) had deletions in the proximal part of AZF regions near SRY gene. No MICRODELETIONs were seen in the AZFa or SRY gene. Conclusion: Our results emphasize that Y CHROMOSOME MICRODELETION analysis should be carried out in all patients with idiopathic azoospermia or severe OLIGOSPERMIA who are candidates for intracytoplasmic sperm injection.

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    APA: Copy

    OMRANI, M.D., SAMADZADEH, S., BAGHERI, M., & ATTAR, K.. (2006). Y CHROMOSOME MICRODELETIONS IN IDIOPATHIC INFERTILE MEN FROM WEST AZARBAIJAN. UROLOGY JOURNAL, 3(1), 38-43. SID. https://sid.ir/paper/270695/en

    Vancouver: Copy

    OMRANI M.D., SAMADZADEH S., BAGHERI M., ATTAR K.. Y CHROMOSOME MICRODELETIONS IN IDIOPATHIC INFERTILE MEN FROM WEST AZARBAIJAN. UROLOGY JOURNAL[Internet]. 2006;3(1):38-43. Available from: https://sid.ir/paper/270695/en

    IEEE: Copy

    M.D. OMRANI, S. SAMADZADEH, M. BAGHERI, and K. ATTAR, “Y CHROMOSOME MICRODELETIONS IN IDIOPATHIC INFERTILE MEN FROM WEST AZARBAIJAN,” UROLOGY JOURNAL, vol. 3, no. 1, pp. 38–43, 2006, [Online]. Available: https://sid.ir/paper/270695/en

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