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Information Journal Paper

Title

IMMEDIATE INTRAVESICAL INSTILLATION OF MITOMYCIN C AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN PATIENTS WITH LOW-RISK SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF BLADDER

Pages

  220-224

Abstract

 Introduction: The aim of this study was to evaluate the effect of immediate intravesical instillation of MITOMYCIN C after TRANSURETHRAL RESECTION of bladder tumor (TURBT) in patients with low-risk superficial TRANSITIONAL CELL CARCINOMA (TCC).Materials and Methods: A total of 43 patients with low-risk superficial BLADDER CANCER were randomly assigned into two groups after the surgery; 22 patients in group 1 were treated by immediate instillation of MITOMYCIN C after TURBT, and 21 patients in group 2 received placebo. The two groups were compared using urine cytology and cystoscopy during the 24 postoperative months.Results: Recurrence within the first 3 months was reported in none of the patients in group 1 and 5 in group 2 (P=.02). Of these, 4 had recurrence of tumor in the primary site. At 12 and 24 months, there were 1 patient (4.5%) in group 1 and 8 (38.1%) in group 2 with recurrence (P =.007). We had no patients with multifocal recurrence in group 1, but 3 (14.2%) in group 2. Nine-month tumor-free survival rate was 95% in group 1. Three-, 6-, 9-, and 12-month tumor-free survival rates in group 2 were 76%, 71%, 66%, and 62%, respectively (P = .007). None of the patients in group 1 and 3 in group 2 (14.3%) experienced some degrees of tumor progression (P = .06).Conclusions: Immediate instillation of MITOMYCIN C after TURBT seems to be effective in the recurrence reduction and increase of recurrence-free interval at least in short term.

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    APA: Copy

    BARGHI, MOHAMMAD REZA, RAHMANI, M.R., JAHANBIN, M., & HOSSEINI MOGHADAM, S.M.. (2006). IMMEDIATE INTRAVESICAL INSTILLATION OF MITOMYCIN C AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN PATIENTS WITH LOW-RISK SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF BLADDER. UROLOGY JOURNAL, 3(4), 220-224. SID. https://sid.ir/paper/270742/en

    Vancouver: Copy

    BARGHI MOHAMMAD REZA, RAHMANI M.R., JAHANBIN M., HOSSEINI MOGHADAM S.M.. IMMEDIATE INTRAVESICAL INSTILLATION OF MITOMYCIN C AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN PATIENTS WITH LOW-RISK SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF BLADDER. UROLOGY JOURNAL[Internet]. 2006;3(4):220-224. Available from: https://sid.ir/paper/270742/en

    IEEE: Copy

    MOHAMMAD REZA BARGHI, M.R. RAHMANI, M. JAHANBIN, and S.M. HOSSEINI MOGHADAM, “IMMEDIATE INTRAVESICAL INSTILLATION OF MITOMYCIN C AFTER TRANSURETHRAL RESECTION OF BLADDER TUMOR IN PATIENTS WITH LOW-RISK SUPERFICIAL TRANSITIONAL CELL CARCINOMA OF BLADDER,” UROLOGY JOURNAL, vol. 3, no. 4, pp. 220–224, 2006, [Online]. Available: https://sid.ir/paper/270742/en

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